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Strokes

Clinical Trials  |  Add a link  |  Regulations  |  Discussion Board  |  Ask the Nurse | Last Update January 1st. 2009  |  About FDA.COM  | Media Kit

 

""Know Stroke

Stroke is the third leading cause of death in the United States and a leading cause of serious, long-term disability in adults. About 600,000 new strokes are reported in the U.S. each year. The good news is that treatments are available that can greatly reduce the damage caused by a stroke. However, you need to recognize the symptoms of a stroke and get to a hospital quickly. Getting treatment within 60 minutes can prevent disability.

Know Stroke video. This eight-minute video features experts in the field of stroke discussing the symptoms of stroke and what to do, as well as stories from people who have successfully recovered from a stroke. This presentation requires the latest free version of RealPlayer.
What is a stroke?

A stroke, sometimes called a "brain attack," occurs when blood flow to the brain is interrupted. When a stroke occurs, brain cells in the immediate area begin to die because they stop getting the oxygen and nutrients they need to function.

What causes a stroke?

There are two major kinds of stroke.

The first, called an ischemic stroke, is caused by a blood clot that blocks or plugs a blood vessel or artery in the brain. About 80 percent of all strokes are ischemic. The second, known as a hemorrhagic stroke, is caused by a blood vessel in the brain that breaks and bleeds into the brain. About 20 percent of strokes are hemorrhagic.

What disabilities can result from a stroke?

Although stroke is a disease of the brain, it can affect the entire body. The effects of a stroke range from mild to severe and can include paralysis, problems with thinking, problems with speaking, and emotional problems. Patients may also experience pain or numbness after a stroke.


Photo of young womanKnow the Signs

Because stroke injures the brain, you may not realize that you are having a stroke. To a bystander, someone having a stroke may just look unaware or confused. Stroke victims have the best chance if someone around them recognizes the symptoms and acts quickly.



 

What are the symptoms of a stroke?

The symptoms of stroke are distinct because they happen quickly:

  • Sudden numbness or weakness of the face, arm, or leg (especially on one side of the body)
  • Sudden confusion, trouble speaking or understanding speech
  • Sudden trouble seeing in one or both eyes
  • Sudden trouble walking, dizziness, loss of balance or coordination
  • Sudden severe headache with no known cause
What should a bystander do?

If you believe someone is having a stroke – if he or she suddenly loses the ability to speak, or move an arm or leg on one side, or experiences facial paralysis on one side – call 911 immediately.

Streetsign image with text: Trouble Walking Streetsign image with text: Weakness on one side Streetsign image with text: Trouble Seeing Streetsign image with text: Trouble Speaking

Photo of middle-aged womanAct in Time

Stroke is a medical emergency. Every minute counts when someone is having a stroke. The longer blood flow is cut off to the brain, the greater the damage. Immediate treatment can save people's lives and enhance their chances for successful recovery.
 

 

Why is there a need to act fast?

Ischemic strokes, the most common type of strokes, can be treated with a drug called t-PA, that dissolves blood clots obstructing blood flow to the brain. The window of opportunity to start treating stroke patients is three hours, but to be evaluated and receive treatment, patients need to get to the hospital within 60 minutes.

What is the benefit of treatment?

A five-year study by the National Institute of Neurological Disorders and Stroke (NINDS) found that some stroke patients who received t-PA within three hours of the start of stroke symptoms were at least 30 percent more likely to recover with little or no disability after three months.

What can I do to prevent a stroke?
The best treatment for stroke is prevention. There are several risk factors that increase your chances of having a stroke:
  • High blood pressure
  • Heart disease
  • Smoking
  • Diabetes
  • High cholesterol

If you smoke – quit. If you have high blood pressure, heart disease, diabetes, or high cholesterol, getting them under control – and keeping them under control – will greatly reduce your chances of having a stroke.


 

"Know Stroke. Know the Signs. Act in Time.", NINDS. January 2008.
 

NIH Publication No. 08-4872

Back to Stroke Information Page.



 

Prepared by:
Office of Communications and Public Liaison
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892



 

NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency. Advice on the treatment or care of an individual patient should be obtained through consultation with a physician who has examined that patient or is familiar with that patient's medical history.

All NINDS-prepared information is in the public domain and may be freely copied. Credit to the NINDS or the NIH is appreciated.

 

Reference Links - Add a link

Clinical Trials - Add a clinical trial

 top
1
Recruiting
Stroke in Young Fabry Patients (sifap1): Frequency of Fabry Disease in Young Stroke Patients
Condition:
Cerebrovascular Accident 
Intervention:
Other: No intervention 
 
 

 
2
Recruiting
Non-Invasive Brain Stimulation and Occupational Therapy To Enhance Stroke Recovery
Conditions:
Stroke;   Cerebrovascular Accident;   CVA;   Acute Stroke;   Acute Cerebrovascular Accident;   Apoplexy 
Interventions:
Device: Transcranial Direct Current Stimulation;   Device: Transcranial Direct Current Stimulation 
 
 

 
3
Not yet recruiting
Adapting Tools to Implement Stroke Risk Management to Veterans
Conditions:
Ischemic Stroke;   Transient Ischemic Attack 
Interventions:
Behavioral: Physician stroke guideline adherence;   Behavioral: Evaluation of stroke self management 
 
 

 
4
Recruiting
"Mobile Stroke-Unit" for Reduction of the Response Time in Ischemic Stroke
Condition:
Stroke 
Interventions:
Procedure: MSU;   Procedure: OCCM 
 
 

 
5
Not yet recruiting
Use of Deep Transcranial Magnetic Stimulation After Stroke
Condition:
Stroke 
Interventions:
Device: Deep TMS (Transcranial magnetic stimulation);   Device: Brainsway Deep TMS 
 
 

 
6
Recruiting
Role of Obstructive Sleep Apnea in Stroke Appearance
Conditions:
Stroke;   Obstructive Sleep Apnea 
Intervention:
Other: polygraphic study 
 
 

 
7
Recruiting
Stroke in Young Fabry Patients (sifap2): Characterization of the Stroke Rehabilitation
Conditions:
Fabry Disease;   Cerebrovascular Accident 
Intervention:
Other: No intervention 
 
 

 
8
Not yet recruiting
Adaptive Physical Activity for Chronic Stroke
Condition:
Stroke 
Interventions:
Behavioral: APA-Stroke;   Behavioral: Sittercize 
 
 

 
9
Recruiting
The Stroke Warning Information and Faster Treatment Study (SWIFT)
Condition:
Stroke 
Interventions:
Behavioral: interactive educational program;   Behavioral: usual medical care 
 
 

 
10
Recruiting
Insulin Resistance Intervention After Stroke Trial
Conditions:
Stroke;   Myocardial Infarction;   Diabetes 
Interventions:
Drug: pioglitazone;   Drug: placebo 
 
 

 
11
Recruiting
Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS)
Conditions:
Vertebrobasilar Insufficiency;   Ischemic Attack, Transient;   Cerebrovascular Disorder;   Brain Ischemia;   Stroke 
Intervention:
 
 
 

 
12
Recruiting
Ancrod (Viprinex™) for the Treatment of Acute, Ischemic Stroke
Conditions:
Stroke;   Cerebral Ischemia;   Brain Infarction 
Interventions:
Drug: Ancrod (Viprinex);   Drug: Placebo 
 
 

 
13
Recruiting
MR and Recanalization of Stroke Clots Using Embolectomy
Condition:
Stroke 
Intervention:
Procedure: Merci Retriever 
 
 

 
14
Recruiting
TRUST-tPA: Therapeutic Trial Evaluating Efficacy of Telemedicine (TELESTROKE) of Patients With Acute Stroke
Condition:
Acute Stroke 
Intervention:
Procedure: Visio conference system connected to the Tele-stroke network 
 
 

 
15
Recruiting
Patent Foramen Ovale Closure or Anticoagulants Versus Antiplatelet Therapy to Prevent Stroke Recurrence
Conditions:
Ischemic Stroke;   Patent Foramen Ovale;   Atrial Septal Aneurysm;   Migraine 
Interventions:
Drug: aspirin;   Drug: Antivitamins K;   Device: Devices for PFO closure 
 
 

 
16
Recruiting
MRI-DTI as a Predictor of Functional Outcome in Acute Ischemic Stroke
Conditions:
Acute Ischemic Stroke;   Stroke;   Cerebral Stroke;   Cerebrovascular Accident 
Intervention:
 
 
 

 
17
Recruiting
Scandinavian Candesartan Acute Stroke Trial (SCAST)
Condition:
Stroke 
Intervention:
Drug: Candesartan cilexetil 
 
 

 
18
Recruiting
Platelet Hyperreactivity to Aspirin and Stroke
Conditions:
Stroke;   Cerebral Infarction;   Cardiovascular Diseases;   Vascular Diseases;   Atherosclerosis;   Ischemia;   Thrombosis;   Acute Coronary Syndrome 
Intervention:
Drug: Aspirin (platelet sensitive versus platelet hyperreactivity) 
 
 

 
19
Recruiting
Influence of Area of Brain Damage on Brain Reorganization After Chronic Stroke
Conditions:
Central Nervous System Disease;   Cerebrovascular Accident;   Stroke 
Intervention:
 
 
 

 
20
Recruiting
Secondary Prevention of Small Subcortical Strokes Trial
Conditions:
Cerebrovascular Accident;   Hypertension 
Interventions:
Drug: aspirin;   Drug: clopidogrel;   Other: Target of Blood Pressure;   Other: placebo 
 
 

 
21
Recruiting
Japan Statin Treatment Against Recurrent Stroke (J-STARS)
Condition:
Ischemic Stroke 
Intervention:
Drug: Pravastatin 
 
 

 
22
Recruiting
Fluoxetine on Motor Rehabilitation After Ischemic Stroke
Conditions:
Ischemic Stroke;   Motor Impairment 
Interventions:
Drug: fluoxetine;   Drug: placebo 
 
 

 
23
Recruiting
VITATOPS: A Study of VITAmins TO Prevent Stroke
Conditions:
Stroke;   Transient Ischemic Attack 
Interventions:
Drug: folic acid 2mg;   Drug: Vitamin B6 25mg;   Drug: Vitamin B12 500ug 
 
 

 
24
Recruiting
STRokE DOC Arizona TIME - Stroke Team Remote Evaluation Using a Digital Observation Camera
Condition:
Stroke, Acute 
Interventions:
Other: Telephone;   Other: Two way audio/video telemedicine consult 
 
 

 
25
Recruiting
Clinic-Based AMES Treatment of Stroke
Conditions:
Stroke;   Cerebrovascular Accident 
Intervention:
Device: The AMES device 
 
 

 
26
Recruiting
Multidetector Raw CT as a Single Tool in the Setting of Ischemic Stroke
Condition:
Ischemic Stroke 
Intervention:
Device: Multidetector raw CT 
 
 

 
27
Recruiting
Volitional Swallowing in Stroke Patients With Chronic Dysphagia
Conditions:
Stroke;   Dysphagia 
Intervention:
Procedure: Swallowing Training 
 
 

 
28
Recruiting
Quality Assessment in Acute Stroke Care
Condition:
Acute Ischemic Stroke 
Intervention:
 
 
 

 
29
Recruiting
Interventional Management of Stroke (IMS) III Trial
Condition:
Acute Ischemic Stroke 
Interventions:
Drug: IV rt-PA;   Drug: IA rt-PA;   Device: Concentric Merci® Retriever (Retrievers X6 and L5 );   Device: EKOS Micro-Infusion (NeuroWave Infusion) System 
 
 

 
30
Recruiting
Mayo Acute Stroke Trial for Enhancing Recovery
Condition:
Ischemic Stroke 
Intervention:
Drug: donepezil 
 
 

 
31
Recruiting
Levels of Inflammatory Markers in the Treatment of Stroke—An SPS3 Ancillary Study
Conditions:
Hypertension;   Stroke 
Intervention:
 
 
 

 
 
33
Recruiting
Siblings With Ischemic Stroke Study
Condition:
Stroke 
Intervention:
 
 
 

 
34
Recruiting
EARLY 3-Months Aggrenox Treatment Started Within 24 Hrs of Ischemic Stroke Onset vs. After One Week 100 mg ASA
Condition:
Cerebrovascular Accident 
Interventions:
Drug: Aggrenox bid (ASA 25mg/Dipyridamole ER 200mg;   Drug: ASA 100 mg qd 
 
 

 
35
Recruiting
A Pilot Study of Neuro Hand Orthosis Program In Stroke Upper Limb Rehabilitation
Condition:
Paralytic Stroke 
Interventions:
Other: Conventional upper limb stroke rehabilitation;   Device: Neuro Hand Orthosis Program (NHOP) 
 
 

 
36
Recruiting
Field Administration of Stroke Therapy - Magnesium (FAST-MAG) Trial
Condition:
Cerebrovascular Accident 
Interventions:
Drug: magnesium sulfate;   Drug: placebo 
 
 

 
37
Recruiting
Balance Recovery and Training on Fall Prevention in Stroke
Condition:
Stroke 
Intervention:
Behavioral: Balance and Exercise 
 
 

 
38
Not yet recruiting
Balance Recovery and Training on Fall Prevention in Stroke
Condition:
Stroke 
Intervention:
Behavioral: Balance and Exercise 
 
 

 
39
Recruiting
Sleep Apnea Treatment After Stroke (SATS)
Conditions:
Obstructive Sleep Apnea;   Stroke 
Interventions:
Device: continuous positive airway pressure or CPAP;   Device: sham CPAP 
 
 

 
40
Recruiting
Reshaping Exercise Habits and Beliefs (REHAB)
Conditions:
Cerebrovascular Accident;   Stroke 
Interventions:
Behavioral: Exercise;   Other: Stroke education 
 
 

 
41
Recruiting
Standard Medical Management in Secondary Prevention of Ischemic Stroke in China
Condition:
Stroke 
Interventions:
Drug: Aspirin / Clopidogrel, Atorvastatin / Simvastatin;   Drug: Asprin / Clopidogrel, Atorvastatin / Simvastatin 
 
 

 
42
Recruiting
Albumin in Acute Ischemic Stroke Trial
Condition:
Acute Ischemic Stroke 
Interventions:
Drug: human serum albumin infusion;   Drug: placebo 
 
 

 
43
Recruiting
Functional Electrical Stimulation (FES) for Upper Extremity Recovery in Stroke
Conditions:
Stroke, Acute;   Stroke;   Hemiparesis 
Intervention:
Device: NMES device with EMG-triggered and Cyclic capabilities 
 
 

 
44
Recruiting
Normobaric Oxygen Therapy in Acute Ischemic Stroke Trial
Condition:
Stroke 
Interventions:
Drug: normobaric oxygen therapy;   Other: room air 
 
 

 
45
Recruiting
Locomotor Experience Applied Post Stroke Trial
Condition:
Stroke 
Interventions:
Behavioral: body weight training program with treadmill;   Behavioral: physical therapist-monitored exercise program;   Behavioral: a non-specific low intensity exercise program 
 
 

 
46
Recruiting
Evaluation of BOTOX® With Rehabilitation Therapy for the Treatment of Wrist and Hand Spasticity in Post-Stroke Patients
Condition:
Stroke 
Interventions:
Drug: Botox and rehab;   Drug: Placebo and rehab 
 
 

 
47
Recruiting
 

 
48
Recruiting
Prognostic Value of Cardiac and Renal Markers in Ischemic Stroke and Transient Ischemic Attack
Conditions:
Ischemic Stroke;   Transient Ischemic Attack 
Intervention:
 
 
 

 
49
Recruiting
Non-Invasive Brain Signal Training to Induce Motor Control Recovery After Stroke
Condition:
Stroke 
Interventions:
Device: Surface functional electrical stimulation (FES);   Other: Motor learning;   Other: Brain computer interface (BCI) training 
 
 

 
50
Recruiting
 
51
Recruiting
Sildenafil (Viagra) Treatment of Subacute Ischemic Stroke
Condition:
Ischemic Stroke 
Interventions:
Drug: Sildenafil (Viagra);   Drug: Sildenafil 
 
 

 
 
53
Recruiting
North Taiwan Stroke Center for Prevention and Treatment
Condition:
Cerebrovascular Accident 
Interventions:
Procedure: education program;   Procedure: nursing program;   Procedure: rehabilitation program 
 
 

 
54
Recruiting
Database for Stroke in Infants and Children
Condition:
Cerebrovascular Accident 
Intervention:
 
 
 

 
55
Recruiting
Carotid Occlusion Surgery Study
Conditions:
Stroke;   Ischemic Attack, Transient;   Cerebral Infarction 
Interventions:
Procedure: extracranial-intracranial bypass surgery;   Other: best medical therapy 
 
 

 
56
Recruiting
Intra-Arterial Versus Systemic Thrombolysis for Acute Ischemic Stroke
Conditions:
Stroke;   Cerebrovascular Accident 
Interventions:
Other: Alteplase IA and/or mechanical thrombolysis;   Drug: Alteplase IV 
 
 

 
57
Recruiting
ICTUS Study: International Citicoline Trial on acUte Stroke
Conditions:
Acute Stroke;   Cerebral Infarction 
Interventions:
Drug: Citicoline;   Drug: Placebo 
 
 

 
58
Recruiting
Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke
Condition:
Stroke 
Interventions:
Procedure: hypothermia;   Drug: tissue plasminogen activator 
 
 

 
59
Recruiting
Levetiracetam Versus Carbamazepine in Post-Stroke Late Onset Crisis
Conditions:
Epileptic Seizures;   Stroke 
Interventions:
Drug: Levetiracetam;   Drug: Carbamazepine 
 
 

 
60
Recruiting
The Second Prevention Trial for Ischemic Stroke With Dengzhan Shengmai Capsule
Condition:
Stroke 
Interventions:
Drug: Dengzhan Shengmai capsule;   Drug: placebo 
 
 

 
61
Recruiting
Continuous Positive Airway Pressure for the Treatment of Stroke
Conditions:
Acute Ischemic Stroke;   Sleep Apnea 
Intervention:
Procedure: continuous positive airway pressure 
 
 

 
62
Not yet recruiting
Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis
Condition:
Ischemic Stroke 
Interventions:
Device: Wingspan intracranial stent with Gateway balloon;   Other: Intensive Medical Therapy 
 
 

 
63
Not yet recruiting
Participative Rehabilitation in Stroke Patients
Condition:
Stroke 
Interventions:
Behavioral: Case management;   Behavioral: Case management 
 
 

 
64
Recruiting
Swiss Intravenous and Intra-Arterial Thrombolysis for Treatment of Acute Ischemic Stroke Registry
Condition:
Ischemic Stroke 
Interventions:
Procedure: Intravenous Thrombolysis;   Procedure: Intraarterial Thrombolysis 
 
 

 
65
Recruiting
Prognostic Significance of the Baroreflex Sensitivity Changes After Acute Ischemic Stroke
Conditions:
Cerebrovascular Accident;   Baroreflexes;   Autonomic Nervous System Diseases 
Intervention:
 
 
 

 
66
Recruiting
Adjunctive Drug Treatment for Ischemic Stroke Patients
Condition:
Cerebrovascular Accident 
Intervention:
Drug: Eptifibatide in combination w Aspirin, Tinzaparin sodium 
 
 

 
67
Recruiting
Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke
Condition:
Stroke 
Interventions:
Drug: Desmoteplase;   Drug: Placebo 
 
 

 
68
Recruiting
Factors Influencing Stroke Outcome
Condition:
Stroke 
Intervention:
 
 
 

 
69
Recruiting
The Effect of Insulin on Infarct Size and Neurologic Outcome After Acute Stroke
Conditions:
Acute Ischemic Stroke;   Hyperglycemia 
Intervention:
Drug: Insulin 
 
 

 
70
Recruiting
Tactile Learning in Stroke Patients
Condition:
Stroke 
Intervention:
 
 
 

 
71
Recruiting
3T Stroke MRT for Examining Mismatch in 1000+
Condition:
Acute (< 24 Hours) Stroke or TIA 
Intervention:
 
 
 

 
72
Recruiting
COMbination of Clopidogrel and Aspirin for Prevention of Early REcurrence in Acute Atherothrombotic Stroke
Condition:
Stroke 
Interventions:
Drug: Clopidogrel;   Drug: Clopidogrel placebo;   Drug: Aspirin 
 
 

 
73
Not yet recruiting
The Role of Dyslipidemia and Extended-Release Niacin in Stroke Recovery
Condition:
Ischemic Stroke 
Interventions:
Drug: Extended-Release Niacin;   Drug: Extended-Release Niacin;   Drug: Placebo 
 
 

 
 
75
Recruiting
Study to Determine The Effect of a Drug Called Neupogen on Stroke Recovery
Condition:
Ischemic Stroke 
Intervention:
Drug: Filgrastim 
 
 

 
76
Recruiting
Study of Abnormal Blood Clotting in Children With Stroke
Conditions:
Abnormalities;   Blood Coagulation Disorder;   Brain Disease;   Cerebrovascular Accident;   Vascular Disease 
Intervention:
 
 
 

 
77
Recruiting
The Efficacy of Treadmill Training in Establishing Walking After Stroke
Condition:
Stroke 
Interventions:
Procedure: treadmill walking with partial weight support;   Procedure: assisted overground walking 
 
 

 
78
Recruiting
Efficacy and Safety of Continuous Intravenous Versus Usual Subcutaneous Insulin in Acute Ischemic Stroke
Conditions:
Acute Stroke;   Acute Cerebral Ischemia 
Intervention:
Drug: Insulin 
 
 

 
79
Recruiting
Stroke Canada Optimization of Rehabilitation by Evidence Implementation Trial SCORE-IT)
Condition:
Stroke 
Intervention:
Behavioral: Knowledge translation intervention package 
 
 

 
80
Not yet recruiting
The Effectiveness and Safety of Butylphthalide Soft Capsules in Secondary Prevention of Ischemic Stroke Trial
Conditions:
Stroke;   Transient Ischemic Attack 
Interventions:
Drug: Butylphthalide Soft Capsules;   Drug: Aspirin 
 
 

 
81
Recruiting
Safety and Efficacy of NeuroFlo Technology in Ischemic Stroke (SENTIS)
Condition:
Cerebrovascular Accident 
Interventions:
Device: NeuroFlo™ catheter;   Other: Control 
 
 

 
82
Recruiting
Study of Tenecteplase (TNK) in Acute Ischemic Stroke (TNK-S2B)
Condition:
Stroke 
Interventions:
Drug: tenecteplase;   Drug: tissue plasminogen activator, tPA 
 
 

 
83
Recruiting
Cognitive and Emotional Impairment After Stroke
Conditions:
Stroke;   Cognitive Impairment;   Emotional Symptoms;   Vascular Risk-Factors;   Vascular Dementia 
Intervention:
Other: Multifactorial vascular-risk-factor-intervention 
 
 

 
84
Recruiting
Evaluating the Remote Effects of Stroke With MRI and PET Scans
Condition:
Cerebrovascular Accident 
Intervention:
 
 
 

 
85
Recruiting
A Comparison of Two Intensive Walking Training Interventions in Community Dwelling Individuals With History of Stroke
Condition:
Stroke 
Interventions:
Behavioral: Motor Learning Walking Program;   Behavioral: Body Weight Supported Treadmill Training 
 
 

 
86
Recruiting
Treatment of Hand Dysfunction After Stroke
Condition:
Stroke 
Intervention:
Device: Functional Electrical Stimulation 
 
 

 
87
Not yet recruiting
Functional Recovery in Stroke Patients With Task-Specific Robot-Aided Arm Therapy
Conditions:
Stroke;   Upper Extremity Paresis 
Interventions:
Device: robot therapy (ARMin);   Other: conventional therapy 
 
 

 
88
Not yet recruiting
A RCT to Establish the Effectiveness of Intermittent Pneumatic Compression to Prevent Post Stroke DVT
Condition:
Stroke 
Intervention:
Device: Intermittant Pnueumatic compression 
 
 

 
89
Not yet recruiting
Study of Aspirin and TPA in Acute Ischemic Stroke
Condition:
Acute Ischemic Stroke 
Intervention:
Drug: Aspirin 
 
 

 
90
Recruiting
tDCS and Physical Therapy in Stroke
Condition:
Cerebrovascular Accident 
Interventions:
Device: Active transcranial Direct Current Stimulation / Constraint Induced Movement Therapy;   Device: Sham transcranial Direct Current Stimulation / Constraint Induced Movement Therapy 
 
 

 
91
Recruiting
Influence of Assistive Device Use While Performing Dual Task in Patients With Stroke
Condition:
Stroke 
Intervention:
Device: Standard cane 
 
 

 
92
Recruiting
The Post Stroke Preventive Trial (PREVENT). A RCT Nested in a Cohort Study
Conditions:
Cerebrovascular Accident;   Transient Ischemic Attack;   Myocardial Infarction 
Intervention:
Behavioral: blood pressure control 
 
 

 
93
Recruiting
Argatroban TPA Stroke Study
Condition:
Acute Ischemic Stroke 
Intervention:
Drug: argatroban 
 
 

 
94
Not yet recruiting
Force Feedback Joystick in Upper Limb Rehabilitation Following Stroke
Condition:
Stroke 
Intervention:
Device: Exercise with force feedback joystick 
 
 

 
95
Recruiting
Activated Protein C in Acute Stroke Trial
Condition:
Stroke 
Intervention:
Drug: Activated Protein C 
 
 

 
96
Recruiting
Phase I Study: Evaluate the Safety and Performance of the MindFrame™ IRIIS™ Device
Condition:
Ischemic Stroke 
Intervention:
Device: MindFrame™ IRIIS™ System 
 
 

 
97
Recruiting
Gait Training for Persons With Stroke
Conditions:
Stroke;   Middle Cerebral Artery Infarction 
Interventions:
Behavioral: Lokomat - Physical therapy;   Behavioral: Physical therapy - Lokomat 
 
 

 
98
Recruiting
Neurobiological Principles Applied to the Rehabilitation of Stroke Patients
Condition:
Stroke 
Interventions:
Drug: Sinemet, ritalin, amphetamine, and placebo;   Device: Transcranial magnetic stimulation (TMS);   Other: Combined drug treatment and TMS 
 
 

 
99
Recruiting
Mirror-Box Training in Adults With Chronic Hemiparesis Secondary to Stroke
Condition:
Stroke 
Intervention:
Behavioral: motor training 
 
 

 
100
Recruiting
CHInese Medicine NeuroAid Efficacy on Stroke Recovery
Conditions:
Cerebral Infarction;   Stroke 
Interventions:
Drug: NeuroAid;   Drug: Neuroaid matched Placebo 
 
 
101
Recruiting
PBWST (Partial Body-Weight Supported Treadmill Training) and Muscle Power Training After Sub-Acute Stroke
Condition:
Stroke 
Interventions:
Procedure: Partial Body-weight supported Treadmill Training;   Procedure: PBWST + Power training;   Procedure: "Usual" physiotherapy care 
 
 

 
102
Recruiting
Walking Therapy In Hemiparetic Stroke Patients Using Robotic-Assisted Treadmill Training
Conditions:
Hemiparesis;   Stroke 
Intervention:
Device: Lokomat (Robotic Orthosis) combined with slat belt treadmill 
 
 

 
103
Recruiting
 

 
104
Recruiting
Gait Training For Acute Stroke: Functional Neuromuscular Stimulation (FNS) and Weight Supported Treadmill Training
Condition:
Stroke 
Interventions:
Device: Electrical Stimulation with Intramuscular Electrodes;   Procedure: Body Weight Supported Treadmill Training 
 
 

 
105
Recruiting
An Implantable Microstimulator for the Treatment of Chronic Shoulder Pain in Chronic Post-Stroke Subjects
Condition:
Chronic Shoulder Pain in Chronic Post-Stroke 
Interventions:
Device: Bioness Battery Powered Microstimulator;   Device: Battery-Powered Microstimulator (BBPM) 
 
 

 
106
Recruiting
Sub-Acute Stroke Rehabilitation With AMES
Condition:
Cerebrovascular Stroke 
Interventions:
Device: AMES device;   Device: AMES device (sham);   Device: AMES device 
 
 

 
107
Recruiting
Brain and Coordination Changes Induced By Robotics and FES Treatment Following Stroke
Conditions:
Cerebrovascular Accident;   Stroke;   Cerebral Stroke 
Interventions:
Device: Robotics training for shoulder elbow.;   Device: Surface Functional Neuromuscular Stimulation 
 
 

 
108
Not yet recruiting
 

 
109
Recruiting
Surgical Manipulation of the Aorta and Cerebral Infarction
Conditions:
Coronary Heart Disease;   Stroke;   Cerebral Infarction 
Interventions:
Procedure: OBCAB (Off Pump Coronary Artery Bypass Grafting);   Procedure: CABG (coronary artery bypass grafting) 
 
 

 
110
Recruiting
Internally Versus Externally Guided Body Weight-Supported Treadmill Training (BWSTT) for Locomotor Recovery Post-Stroke
Condition:
Cerebrovascular Accident 
Intervention:
Behavioral: Rehabilitation: Two Forms of Locomotor Training for Gait 
 
 

 
111
Recruiting
Study of a Neuroprotective Drug to Limit the Extent of Damage From an Ischemic Stroke
Condition:
Stroke, Acute 
Intervention:
Drug: Minocycline 
 
 

 
112
Recruiting
Development of a Comprehensive ADL Scale for Stroke Patients
Condition:
Cerebrovascular Accidents 
Intervention:
 
 
 

 
113
Recruiting
 

 
114
Not yet recruiting
Effectiveness and Safety of Rhubarb for the Treatment of Patients Who Have Suffered From a Stroke
Conditions:
Pneumonia;   Acute Stroke 
Interventions:
Drug: rhubarb;   Drug: placebo 
 
 

 
115
Recruiting
Training the Arm and Hand After Stroke Using Auditory Rhythm Cues
Conditions:
Stroke;   Hemiplegia 
Interventions:
Behavioral: Constraint-Induced Movement Therapy + auditory rhythm cues;   Behavioral: Constraint-Induced Movement Therapy 
 
 

 
116
Recruiting
Effectiveness of Virtual Reality Exercises in STroke Rehabilitation (EVREST)
Condition:
Stroke 
Interventions:
Other: Recreational therapy activities;   Other: Nintendo Wii 
 
 

 
117
Recruiting
hsCRP in Japan Statin Treatment Against Recurrent Stroke (J-STARS hsCRP)
Condition:
Ischemic Stroke 
Intervention:
Drug: Pravastatin 
 
 

 
118
Recruiting
Virtual Reality Training Program for Ambulatory Patients With Chronic Gait Deficits After Stroke
Condition:
Stroke 
Intervention:
Device: Virtual reality system (CAREN™ Integrated Reality System; MOTEK BV, Netherlands). 
 
 

 
119
Recruiting
Shoulder, or Elbow, or Wrist: What Should we Train First After a Stroke?
Condition:
Stroke 
Interventions:
Device: rehabilitation robotics;   Procedure: Movement therapy 
 
 

 
120
Recruiting
Transesophageal Echocardiography to Identify pAtients With Low Risk of Stroke in Atrial Fibrillation - TIARA Pilot Study
Conditions:
Atrial Fibrillation;   Stroke 
Intervention:
Procedure: Transoesophageal echocardiography 
 
 

 
121
Not yet recruiting
Extended Stroke Unit Service in Bergen
Condition:
Stroke 
Interventions:
Other: Early supported discharge with day institution rehabilitation;   Other: Early supported discharge with home rehabilitation 
 
 

 
122
Recruiting
Natural History of Stroke: Cause and Development
Conditions:
Cerebrovascular Accident;   Transient Ischemic Attack 
Intervention:
 
 
 

 
123
Not yet recruiting
Improving Stroke Rehabilitation: Spacing Effect and d-Cycloserine
Condition:
Stroke 
Interventions:
Drug: D-cycloserine + distributed treatment;   Behavioral: D-cycloserine + condensed treatment;   Drug: Placebo + distributed treatment;   Behavioral: Placebo + condensed treatment 
 
 

 
124
Recruiting
Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion
Condition:
Acute Ischemic Stroke 
Intervention:
Drug: Deferoxamine 
 
 

 
125
Recruiting
Effects of Whole Body Vibration in Subacute Stroke Patients
Condition:
Stroke 
Interventions:
Device: Whole body vibration therapy;   Other: standing on the vibration platform but no vibration will be applied 
 
 

 
126
Recruiting
Investigation of Acceptable Dose of Mobilisation and Tactile Stimulation to Enhance Upper Limb Recovery After Stroke
Condition:
Stroke 
Interventions:
Behavioral: Conventional UK physical therapy (Con UK PT);   Behavioral: Con UK PT + 30 minutes/day Mobilisation & Tactile Stimulation (MTS);   Behavioral: Con UK PT + 60 minutes a day MTS;   Behavioral: Con UK PT + 120 minutes a day MTS 
 
 

 
127
Recruiting
 

 
128
Recruiting
Sex Differences in Vascular Markers of Stroke Risk
Condition:
Stroke 
Intervention:
 
 
 

 
129
Recruiting
Efficacy of a Mechanical Gait Repetitive Training Technique in Hemiparetic Stroke Patients
Conditions:
Hemiplegia;   Stroke 
Intervention:
Device: Gait trainer 
 
 

 
130
Recruiting
Treatments for Recovery of Hand Function in Acute Stroke Survivors
Conditions:
Stroke, Acute;   Stroke;   Hemiparesis;   Hemiplegia 
Intervention:
Device: Neuromuscular electrical stimulator 
 
 

 
131
Not yet recruiting
Dopamine Agonist for Hemispatial Neglect and Motor Deficit Post Stroke
Conditions:
Right Hemisphere Stroke;   Hemispatial Neglect;   Motor Deficits 
Intervention:
Drug: Rotigotine 
 
 

 
132
Recruiting
Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies
Conditions:
Aphasia;   Nonfluent Aphasia;   Stroke 
Intervention:
 
 
 

 
133
Recruiting
Study of Robot-Assisted Arm Therapy for Acute Stroke Patients
Conditions:
Acute Stroke;   Paresis 
Interventions:
Device: Reo Go robotic arm trainer;   Procedure: Conventional Therapy 
 
 

 
134
Recruiting
Mechanisms of Upper-Extremity Motor Recovery in Post-Stroke Hemiparesis
Condition:
Cerebrovascular Accident 
Intervention:
Other: Upper Extremity Rehabilitation 
 
 

 
135
Recruiting
Measurement of Pulse Wave Velocity in Spinal Cord Injury and Stroke Patients
Conditions:
Cerebrovascular Accident;   Spinal Cord Injury 
Intervention:
 
 
 

 
136
Recruiting
 

 
137
Recruiting
Client Centred 'Tune-Ups': do They Enhance Community Reintegration After Stroke?
Condition:
Stroke 
Intervention:
Behavioral: physical rehabilitation 
 
 

 
138
Not yet recruiting
Skeletal Muscle Properties and the Metabolic Cost of Walking Post-Stroke
Condition:
Stroke 
Interventions:
Other: Treadmill walking;   Other: Magnetic resonance spectroscopy 
 
 

 
139
Recruiting
 

 
140
Recruiting
Merci Registry - Real World Use of the Merci Retrieval System in Acute Ischemic Stroke
Condition:
Ischemic Stroke 
Intervention:
Procedure: Mechanical Embolectomy 
 
 

 
141
Recruiting
A Study to Evaluate the Effects of the Neuroflo Device in People Who Have Had a Stroke
Condition:
Acute Stroke 
Intervention:
Device: NeuroFlo Catheter 
 
 

 
142
Recruiting
 

 
 
144
Recruiting
Usefulness of Nasal CPAP Treatment in Patients With a First Ever Stroke and Sleep Apnoea Syndrome
Conditions:
Sleep Apnea;   Stroke;   Cardiovascular Disease 
Intervention:
Device: Nasal CPAP (Continuous Positive Airway Pressure) 
 
 

 
145
Recruiting
Stroke With Transfusions Changing to Hydroxyurea (SWiTCH)
Conditions:
Hemochromatosis;   Cerebrovascular Accident;   Anemia, Sickle Cell;   Hematologic Diseases 
Interventions:
Procedure: Red Cell Transfusions;   Procedure: Iron Chelation;   Drug: Hydroxyurea;   Procedure: Phlebotomy 
 
 

 
146
Recruiting
Smoking Cessation Intervention After Stroke or Transient Ischaemic Attack.
Conditions:
Stroke;   Transient Ischemic Attack 
Intervention:
Behavioral: Smoking cessation 
 
 

 
147
Recruiting
Wearable Robotic Functional Assistance for Stroke Rehabilitation
Condition:
CVA (Cerebrovascular Accident) 
Intervention:
Device: myomo e100 neurorobotic elbow brace 
 
 

 
148
Recruiting
mCIMT and Eye Patching for Neglect Rehabilitation Post Stroke: A Longitudinal Study of Separate and Combined Effects
Conditions:
Stroke;   Hemispatial Neglect 
Intervention:
Device: mCIMT combined with or without eye patching 
 
 

 
149
Recruiting
Use of the BrainPort® Balance Device to Improve Balance in Adults With Balance Deficits Due to Stroke
Condition:
Cerebrovascular Accident 
Intervention:
Device: BrainPort Balance Device 
 
 

 
150
Recruiting
Fangshan / Family-Based Ischemic Stroke Study In China
Condition:
Stroke 
Intervention:
 
 
 
151
Recruiting
Evaluating Neuroprotection in Aneurysm Coiling Therapy
Condition:
Stroke 
Interventions:
Drug: NA-1;   Drug: Placebo 
 
 

 
152
Recruiting
Transcranial Galvanic Stimulation After Stroke
Condition:
Stroke 
Intervention:
Device: transcranial galvanic stimulation 
 
 

 
153
Recruiting
The IMPACT of BIOTRONIK Home Monitoring Guided Anticoagulation on Stroke Risk in Patients With Implanted ICD and CRT-D Devices
Conditions:
Atrial Fibrillation;   Atrial Flutter;   Stroke;   Systemic Embolism;   Major Bleeding 
Interventions:
Drug: warfarin, according to a predefined anticoagulation plan;   Drug: warfarin, physician-directed based on conventional criteria 
 
 

 
154
Recruiting
 

 
155
Recruiting
Interdisciplinary Home Rehabilitation of Patients With Stroke. A Randomised Controlled Intervention Trial.
Condition:
Acute Stroke 
Interventions:
Other: Home rehabilitation;   Other: Regular rehabilitation 
 
 

 
156
Recruiting
The Role of Cerebral Hemodynamics in Moyamoya Disease
Conditions:
Moyamoya;   Stroke 
Intervention:
 
 
 

 
157
Recruiting
Functional Electrical Stimulation (FES) Assisted Walking: Enhancement of Walking Function After Stroke
Condition:
Stroke 
Interventions:
Device: Compex Motion Stimulator;   Device: Compex Motion Stimulator 
 
 

 
158
Recruiting
Nutritional Therapy for Stroke Patients
Conditions:
Stroke;   Malnutrition;   Weight Loss;   Dysphagia 
Intervention:
Procedure: Nutritional support 
 
 

 
159
Recruiting
Fabry : National Initiative of Screening
Condition:
Ischemic Stroke Hospitalized 
Intervention:
Procedure: Blood sample 
 
 

 
160
Recruiting
Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia
Conditions:
Stroke;   Coronary Artery Disease;   Arrhythmia 
Intervention:
Procedure: Digital subtraction angiography and 24-hour simultaneous recorder of electrocardiograph 
 
 

 
161
Recruiting
Impact of Left Atrial Appendage Exclusion on Short-Term Clinical Outcomes and Long-Term Stroke Incidence
Conditions:
Atrial Fibrillation;   Thromboembolism;   Cerebrovascular Accident 
Intervention:
Procedure: Left Atrial Appendage Ligation 
 
 

 
162
Recruiting
Effects of Two Different Kinds of Exercise on Stroke Rehabilitation
Conditions:
Cerebrovacular Accident;   Paresis 
Intervention:
 
 
 

 
163
Recruiting
Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation
Conditions:
Atrial Fibrillation;   Atrial Flutter 
Interventions:
Drug: warfarin;   Drug: apixaban 
 
 

 
 
165
Recruiting
Blood Pressure Lowering in Acute Stroke Trial (BLAST)
Condition:
Cerebrovascular Accident 
Intervention:
Drug: Valsartan 
 
 

 
166
Not yet recruiting
Home-Based Telehealth Stroke Care: A Randomized Trial for Veterans
Condition:
Cerebrovascular Accident 
Interventions:
Behavioral: Tele-visit intevention;   Behavioral: In-home messaging device.;   Behavioral: Usual care 
 
 

 
167
Recruiting
Evaluation of Whether Functional Strength Training Can Enhance Recovery of Mobility After Stroke
Condition:
Stroke 
Interventions:
Behavioral: Conventional UK Physical therapy;   Behavioral: Increased intensity of UK conventional physical therapy;   Behavioral: UK conventional physical therapy plus functional strength training 
 
 

 
168
Recruiting
The Effect of Hyperbaric Oxygen on Patients Suffering From Neurologic Deficiency Due to Stroke
Conditions:
Chronic Neurological Deficiency;   Stroke 
Intervention:
Procedure: Hyperbaric Oxygen Therapy (HBOT) 
 
 

 
169
Recruiting
Effect of Continuous Positive Airway Pressure (CPAP) on Cognitive and Functional Performance in Stroke Patients With Obstructive Sleep Apnea
Conditions:
Sleep Apnea, Obstructive;   Cerebrovascular Accident 
Intervention:
Device: Nasal Continuous positive airway pressure - Tyco 420G 
 
 

 
 
171
Recruiting
Locomotor Training (Walking Therapy) Post Stroke
Condition:
Stroke 
Intervention:
Behavioral: locomotor training 
 
 

 
172
Recruiting
Neuropathic Investigation and Anticholinergic Treatment of Bladder Dysfunction in Diabetes and Stroke Patients
Conditions:
Urinary Incontinence;   Bladder Dysfunction 
Intervention:
Drug: Detrol LA 
 
 

 
173
Recruiting
Inflammatory Abnormalities in Muscle After Stroke: Effects of Exercise
Conditions:
Stroke;   Inflammation 
Intervention:
Behavioral: Treadmill exercise 
 
 

 
174
Recruiting
Evaluation of Whether Functional Strength Training Can Enhance Motor Recovery of the Upper Limb After Stroke
Condition:
Stroke 
Interventions:
Behavioral: Conventional UK physical therapy;   Behavioral: Increased intensity of UK conventional physical therapy (PT);   Behavioral: UK conventional PT plus functional strength training 
 
 

 
175
Recruiting
Strength Training and Stroke
Condition:
Stroke 
Interventions:
Behavioral: Constraint-Induced Movement Therapy + strength training;   Behavioral: Constraint-Induced Movement Therapy + range of motion 
 
 

 
176
Recruiting
Trial to Assess the Effects of SCH 530348 in Preventing Heart Attack and Stroke in Patients With Atherosclerosis (TRA 2°P - TIMI 50) (Study P04737)
Conditions:
Atherosclerosis;   Ischemia;   Myocardial Infarction;   Cerebrovascular Accident 
Interventions:
Drug: SCH 530348;   Drug: Placebo 
 
 

 
177
Recruiting
Walking Study for Stroke Rehabilitation
Condition:
Stroke 
Interventions:
Behavioral: Daily reinforcement of walking speed (DRS);   Behavioral: No reinforcement of walking speed (NRS) 
 
 

 
178
Recruiting
 

 
179
Recruiting
Efficacy and Safety of Stent Implantation in Symptomatic Extra- and Intracranial Artery Stenosis
Conditions:
Stroke;   Transient Ischemic Attack;   Atherosclerosis;   Stenosis;   Stents 
Interventions:
Device: Stent implantation (Wingspan, Coroflex, and TiTAN2);   Drug: Standard medical treatment 
 
 

 
180
Recruiting
Motor Learning in Stroke Patients:
Condition:
Stroke 
Intervention:
 
 
 

 
181
Recruiting
Silent Cerebral Infarct Multi-Center Clinical Trial
Conditions:
Sickle Cell Anemia;   Stroke 
Intervention:
Procedure: transfusion therapy 
 
 

 
182
Recruiting
Evaluation of Robotic Arm Rehabilitation in Stroke Patients
Condition:
Stroke 
Interventions:
Device: Robotic Upper Extremity Neurorehabilitation;   Other: Traditional Upper Extremity Exercise Group 
 
 

 
183
Recruiting
ICP Waveform Analysis in Stroke Patients
Condition:
Stroke 
Intervention:
 
 
 

 
184
Recruiting
Autologous Bone Marrow Stem Cells in Ischemic Stroke.
Conditions:
Stroke, Acute;   Infarction, Middle Cerebral Artery 
Intervention:
Procedure: Infusion of autologous CD34+ stem cells into middle cerebral artery 
 
 

 
185
Not yet recruiting
Autologous Bone Marrow Stem Cells in Middle Cerebral Artery Acute Stroke Treatment.
Conditions:
Stroke, Acute;   Infarction, Middle Cerebral Artery 
Intervention:
Procedure: Infusion on autologous CD34+ stem cells into middle cerebral artery 
 
 

 
186
Recruiting
Thriving, Activity and Social Participation After Stroke
Condition:
Stroke 
Interventions:
Behavioral: Group intervention inspired by Lifestyle Redesign;   Behavioral: Group intervention inspired by Lifestyle redesign 
 
 

 
187
Recruiting
Transfer of Grasp Control Across Hands After Stroke
Condition:
Stroke With Hemiparesis 
Intervention:
Behavioral: Transfer of grasp control across hands 
 
 

 
188
Recruiting
 

 
189
Recruiting
Comparison of Two Strategies for Glycemic Control in Acute Ischemic Stroke
Condition:
Acute Ischemic Stroke 
Interventions:
Other: Carbohydrate restrictive strategy;   Drug: Intensive insulin therapy 
 
 

 
190
Recruiting
Coronary Arteriosclerosis in Patients With Acute Ischemic Stroke
Conditions:
Ischemic Stroke;   Myocardial Ischemia;   Coronary Arteriosclerosis 
Intervention:
 
 
 

 
191
Recruiting
Muscular Strengthening for Paretic Knee Flexor and Extensor by Conventional Physiotherapy on Chronic Hemiplegic Stroke Patients
Conditions:
Hemiplegia;   Stroke 
Interventions:
Other: Muscular Strengthening for paretic knee flexor and extensor;   Other: conventional physiotherapy 
 
 

 
192
Recruiting
Safety and Preliminary Efficacy Study of SA4503 in Subjects Recovering From Ischemic Stroke
Condition:
Ischemic Stroke 
Interventions:
Drug: placebo;   Drug: SA4503 Low;   Drug: SA4503 High 
 
 

 
193
Recruiting
The Effect of Losartan Versus Amlodipine-Based Therapy in Ischemic Stroke
Condition:
Ischemic Stroke 
Interventions:
Drug: losartan;   Drug: amlodipine 
 
 

 
194
Recruiting
Estimating Volume Using LiDCO
Conditions:
Brain Injury;   Ischemic Stroke;   Hemorrhagic Stroke 
Intervention:
 
 
 

 
195
Recruiting
A Study on the Use of Tanakan® for Recovery of Neurological Impairment Following Ischaemic Stroke
Conditions:
Stroke, Acute;   Neurological Impairment 
Interventions:
Drug: EGb761 (Tanakan) and acetylsalicylic acid;   Drug: Placebo and acetylsalicylic acid 
 
 

 
196
Recruiting
Cilostazol-Aspirin Therapy Against Recurrent Stroke With Intracranial Artery Stenosis
Condition:
Cerebrovascular Disorders 
Intervention:
Drug: Asprin, Cilostazol 
 
 

 
197
Not yet recruiting
Exercise for Swallowing Problems After Stroke
Conditions:
Cerebrovascular Accident;   Deglutition Disorders 
Interventions:
Device: lingual press;   Behavioral: effortful swallowing;   Behavioral: natural swallowing;   Behavioral: non-oral sham (control) exercise 
 
 

 
198
Recruiting
IV Double and Triple Concentrated Nicardipine for Stroke and ICH
Condition:
Hypertension 
Intervention:
Drug: Nicardipine 
 
 

 
199
Recruiting
The Role of Cytokine-Serotonin Interactions in Post-Stroke Depression
Condition:
Depression 
Intervention:
Drug: citalopram (celexa) 
 
 

 
200
Recruiting
Comparison of Psychometric Properties of Three Depression Measures in Patients With Stroke
Condition:
Cerebrovascular Accidents 
Intervention: