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Smoking Issues

Clinical Trials  |  Add a link  |  Regulations  |  Discussion Board  |  Ask the Nurse | Last Update January 1st. 2009  |  About FDA.COM  | Media Kit

Also called: Cigar smoking, Cigarette smoking, Pipe smoking, Tobacco smoking

There's no way around it. Smoking is bad for your health. Smoking harms nearly every organ of the body. Cigarette smoking causes 87 percent of lung cancer deaths. It is also responsible for many other cancers and health problems. These include lung disease, heart and blood vessel disease, stroke and cataracts. Women who smoke have a greater chance of certain pregnancy problems or having a baby die from sudden infant death syndrome (SIDS). Your smoke is also bad for other people - they breathe in your smoke secondhand and can get many of the same problems as smokers do.

Quitting smoking can reduce your risk of these problems. The earlier you quit, the greater the health benefit.

National Cancer Institute

Cigarette Smoking and Cancer: Questions and Answers

 
Key Points
  • Cigarette smoking causes 87 percent of lung cancer deaths and is responsible for most cancers of the larynx, oral cavity and pharynx, esophagus, and bladder (see Question 1).
  • Secondhand smoke is responsible for an estimated 3,000 lung cancer deaths among U.S. nonsmokers each year (see Question 2).
  • Tobacco smoke contains thousands of chemical agents, including over 60 substances that are known to cause cancer (see Question 3).
  • The risk of developing smoking-related cancers, as well as noncancerous diseases, increases with total lifetime exposure to cigarette smoke (see Question 4).
  • Smoking cessation has major and immediate health benefits, including decreasing the risk of lung and other cancers, heart attack, stroke, and chronic lung disease (see Question 5).

Tobacco use, particularly cigarette smoking, is the single most preventable cause of death in the United States. Cigarette smoking alone is directly responsible for approximately 30 percent of all cancer deaths annually in the United States (1). Cigarette smoking also causes chronic lung disease (emphysema and chronic bronchitis), cardiovascular disease, stroke, and cataracts. Smoking during pregnancy can cause stillbirth, low birthweight, Sudden Infant Death Syndrome (SIDS), and other serious pregnancy complications (2). Quitting smoking greatly reduces a person’s risk of developing the diseases mentioned, and can limit adverse health effects on the developing child.

  1. What are the effects of cigarette smoking on cancer rates?

    Cigarette smoking causes 87 percent of lung cancer deaths (1). Lung cancer is the leading cause of cancer death in both men and women (3). Smoking is also responsible for most cancers of the larynx, oral cavity and pharynx, esophagus, and bladder. In addition, it is a cause of kidney, pancreatic, cervical, and stomach cancers (2, 4), as well as acute myeloid leukemia (2).

  2. Are there any health risks for nonsmokers?

    The health risks caused by cigarette smoking are not limited to smokers. Exposure to secondhand smoke, or environmental tobacco smoke (ETS), significantly increases the risk of lung cancer and heart disease in nonsmokers, as well as several respiratory illnesses in young children (5). (Secondhand smoke is a combination of the smoke that is released from the end of a burning cigarette and the smoke exhaled from the lungs of smokers.) The U.S. Environmental Protection Agency (EPA), the National Institute of Environmental Health Science’s National Toxicology Program, and the World Health Organization’s International Agency for Research on Cancer (IARC) have all classified secondhand smoke as a known human carcinogen—a category reserved for agents for which there is sufficient scientific evidence that they cause cancer (5, 6, 7). The U.S. EPA has estimated that exposure to secondhand smoke causes about 3,000 lung cancer deaths among nonsmokers and is responsible for up to 300,000 cases of lower respiratory tract infections in children up to 18 months of age in the United States each year (5). For additional information on ETS, see the NCI fact sheet Environmental Tobacco Smoke, which can be found at http://www.cancer.gov/cancertopics/factsheet/Tobacco/ETS on the Internet.

  3. What harmful chemicals are found in cigarette smoke?

    Cigarette smoke contains about 4,000 chemical agents, including over 60 carcinogens (8). In addition, many of these substances, such as carbon monoxide, tar, arsenic, and lead, are poisonous and toxic to the human body. Nicotine is a drug that is naturally present in the tobacco plant and is primarily responsible for a person’s addiction to tobacco products, including cigarettes. During smoking, nicotine is absorbed quickly into the bloodstream and travels to the brain in a matter of seconds. Nicotine causes addiction to cigarettes and other tobacco products that is similar to the addiction produced by using heroin and cocaine (9).

  4. How does exposure to tobacco smoke affect the cigarette smoker?

    Smoking harms nearly every major organ of the body (2). The risk of developing smoking-related diseases, such as lung and other cancers, heart disease, stroke, and respiratory illnesses, increases with total lifetime exposure to cigarette smoke (7). This includes the number of cigarettes a person smokes each day, the intensity of smoking (i.e., the size and frequency of puffs), the age at which smoking began, the number of years a person has smoked, and a smoker’s secondhand smoke exposure.

  5. How would quitting smoking affect the risk of developing cancer and other diseases?

    Smoking cessation has major and immediate health benefits for men and women of all ages. Quitting smoking decreases the risk of lung and other cancers, heart attack, stroke, and chronic lung disease. The earlier a person quits, the greater the health benefit. For example, research has shown that people who quit before age 50 reduce their risk of dying in the next 15 years by half compared with those who continue to smoke (3). Smoking low-yield cigarettes, as compared to cigarettes with higher tar and nicotine, provides no clear benefit to health (2). For additional information on quitting smoking, see the NCI fact sheet Questions and Answers About Smoking Cessation, which can be found at http://www.cancer.gov/cancertopics/factsheet/Tobacco/cessation on the Internet.

  6. What additional resources are available?

    For additional information about cancer or tobacco use, call 1–800–4–CANCER or visit the NCI’s Web site about tobacco at http://www.cancer.gov/cancerinfo/tobacco on the Internet.

    For help with quitting smoking, call NCI’s smoking cessation quitline at 1–877–44U–QUIT or visit NCI’s smoking cessation Web site at http://www.smokefree.gov on the Internet.

    Information about the health risks of smoking is also available from Centers for Disease Control and Prevention’s Office on Smoking and Health (OSH) at 1–800–CDC–1311 (1–800–232–1311) or via their Web site at http://www.cdc.gov/tobacco on the Internet.

 

Selected References

     

  1. Ries LAG, Eisner MP, Kosary CL, et al. (eds). SEER Cancer Statistics Review, 1975–2001, National Cancer Institute. Bethesda, MD, 2004 (http://seer.cancer.gov/csr/1975_2001).

     

     

  2. U.S. Department of Health and Human Services. The Health Consequences of Smoking: A Report of the Surgeon General. Rockville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2004.

     

     

  3. American Cancer Society. Cancer Facts and Figures 2004. Atlanta, GA: American Cancer Society, 2004.

     

     

  4. U.S. Department of Health and Human Services. Targeting Tobacco Use: The Nation’s Leading Cause of Death. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2003.

     

     

  5. U.S. Environmental Protection Agency. Respiratory Health Effects of Passive Smoking: Lung Cancer and Other Disorders. Washington, DC: U.S. Environmental Protection Agency, 1992.

     

     

  6. U.S. Department of Health and Human Services. Report on Carcinogens: Tenth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program, 2002.

     

     

  7. International Agency for Research on Cancer. Tobacco Smoke and Involuntary Smoking. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 83. Lyon, France, 2004.

     

     

  8. Centers for Disease Control and Prevention. Tobacco Use in the United States. Retrieved September 30, 2003, from: http://www.cdc.gov/tobacco/overview/tobus_us.htm.

     

     

  9. U.S. Department of Health and Human Services. Nicotine Addiction: A Report of the Surgeon General. Rockville, MD: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, Center for Health Promotion and Education, Office on Smoking and Health, 1988.

     

 

# # #

Related Resources

Publications (available at http://www.cancer.gov/publications)

 

National Cancer Institute (NCI) Resources

 

Cancer Information Service (toll-free)
Telephone: 1–800–4–CANCER (1–800–422–6237)
TTY: 1–800–332–8615

 

 

Online
NCI’s Web site: http://www.cancer.gov
LiveHelp, NCI’s live online assistance: https://cissecure.nci.nih.gov/livehelp/welcome.asp
 

 

Reference Links - Add a link

Clinical Trials - Add a clinical trial

 top
1
Not yet recruiting
Integrating Smoking Cessation Into Routine Primary Care Practice
Condition:
Smoking Cessation 
Interventions:
Behavioral: Smoking cessation training, support, and telephone follow-up;   Behavioral: smoking cessation intervention 
 
 

 
2
Recruiting
Smoking Cessation for Depressed Smokers
Conditions:
Smoking;   Depression 
Interventions:
Behavioral: Smoking Cessation Treatment;   Behavioral: Nicotine Replacement Therapy;   Behavioral: CBASP 
 
 

 
3
Recruiting
Investigate the Exposure to Selected Smoke Constituents in Smokers Switching to Distillation Based Smoking Article
Condition:
Smoking 
Interventions:
Other: Distillation based smoking article (SMAR cigarette);   Other: conventional cigarette;   Other: smoking cessation 
 
 

 
4
Recruiting
Contingency Management and Pharmacotherapy for Smoking Cessation
Condition:
Cigarette Smoking 
Interventions:
Behavioral: contingency management;   Drug: varenicline (smoking cessation medication);   Behavioral: Brief counseling for quitting smoking 
 
 

 
5
Recruiting
Media Literacy to Prevent Adolescent Smoking
Condition:
Smoking Status 
Interventions:
Behavioral: Control;   Behavioral: Media Literacy 
 
 

 
6
Recruiting
Internet Stop Smoking Study - Phase VI
Condition:
Smoking 
Intervention:
Behavioral: UCSF/SFGH Internet Stop Smoking Study site 
 
 

 
7
Recruiting
Smoking Reduction and Cessation Interventions for Chinese
Condition:
Smoking Cessation 
Interventions:
Behavioral: Expert System Only;   Behavioral: Enhanced Expert System 
 
 

 
8
Recruiting
The Effectiveness of Smoking Cessation Guidelines in the Emergency Department
Condition:
Cigarette Smoking 
Intervention:
Behavioral: Smoking cessation guideline implementation 
 
 

 
9
Recruiting
Contingency Management for Smoking in Substance Abusers
Condition:
Cigarette Smoking 
Interventions:
Behavioral: Contingency Management;   Behavioral: Brief smoking cessation counseling 
 
 

 
10
Not yet recruiting
Trial Comparing Different Methods of Support With Stopping Smoking (PORTSSS/Stop Together Trial)
Condition:
Tobacco Smoking 
Interventions:
Behavioral: Proactive telephone support;   Behavioral: Reactive (standard) telephone support;   Drug: Offer of cost-free Nicotine Replacement Therapy 
 
 

 
11
Recruiting
Pennsylvania Adolescent Smoking Study (PASStudy)
Condition:
Smoking Cessation 
Interventions:
Behavioral: Motivational Interviewing (MI);   Behavioral: Structured Brief Advice (SBA) 
 
 

 
12
Recruiting
PROS Smokebusters: Adolescent Smoking Cessation in Pediatric Primary Care
Conditions:
Health Care Quality, Access, and Evaluation;   Smoking Cessation 
Intervention:
Behavioral: smoking cessation, practice change 
 
 

 
13
Recruiting
Knowledge and Perception of Smoking Risks/Consequences
Conditions:
Cigarette Smoking;   Schizophrenia 
Intervention:
 
 
 

 
14
Recruiting
Pharmacogenetics, Emotional Reactivity and Smoking
Conditions:
Tobacco Use Disorder;   Smoking Cessation 
Interventions:
Drug: Bupropion;   Drug: Varenicline;   Drug: Placebo;   Behavioral: Smoking Cessation Counseling 
 
 

 
15
Recruiting
Strategies to Avoid Returning to Smoking
Condition:
Smoking 
Interventions:
Behavioral: CBT addressing postpartum mood and weight concerns;   Behavioral: Supportive Behavioral Therapy 
 
 

 
16
Recruiting
Modeling Stress-Precipitated Smoking Behavior for Medication Development: Guanfacine
Condition:
Smoking 
Interventions:
Drug: guanfacine;   Drug: placebo 
 
 

 
17
Not yet recruiting
Prevent Exposure to Tobacco Smoke at Home [Gesunde Atemluft zu Hause]
Conditions:
Smoking;   Passive Smoking;   Exposure to Environmental Smoke 
Intervention:
Behavioral: bio-chemical feedback and expert system intervention ETS 
 
 

 
18
Recruiting
Smoking Reduction Intervention for Smokers Not Willing to Quit Smoking: a Randomised Control Trial
Condition:
Smoking Cessation 
Interventions:
Procedure: Reduction Intervention + Adherence Intervention;   Behavioral: Reduction Intervention;   Procedure: control 
 
 

 
19
Recruiting
The Reinforcing Mechanisms of Smoking in Adult ADHD
Condition:
ADHD 
Interventions:
Drug: Smoking;   Behavioral: Abstinence;   Drug: Placebo;   Drug: Ritalin, Adderall, or Concerta 
 
 

 
20
Recruiting
Smoking Cessation Program: A Quality Improvement Trial in a Resident Based Outpatient Clinic
Condition:
Smoking 
Interventions:
Drug: nicotine replacement therapy and bupropion;   Behavioral: smoking cessation counseling and referrals 
 
 

 
21
Recruiting
Efficacy of Naltrexone in Women's Smoking Cessation
Conditions:
Smoking;   Smoking Cessation 
Intervention:
Drug: naltrexone (drug) 
 
 

 
22
Not yet recruiting
Improving the Delivery of Smoking Cessation Guidelines in Hospitalized Veterans
Condition:
Cigarette Smoking 
Intervention:
Behavioral: Smoking Cessation Guideline Implementation 
 
 

 
23
Recruiting
rTMS Effects on Smoking Cessation and Cognition in Schizophrenia
Conditions:
Cigarette Smoking;   Schizophrenia 
Interventions:
Procedure: Repetitive Transcranial Magnetic Stimulation (rTMS);   Procedure: Sham Repetitive Transcranial Magnetic Stimulation (rTMS) 
 
 

 
24
Recruiting
Brief Smoking Intervention for Women Undergoing Breast Cancer Surgery
Conditions:
Complication, Postoperative;   Smoking;   Smoking Cessation;   Stress;   Nicotine Dependence 
Intervention:
Behavioral: Brief preoperative smoking intervention 
 
 

 
25
Recruiting
Study of TA-NIC to Assess the Efficacy and Safety of the Vaccine as an Aid to Smoking Cessation
Condition:
Smoking 
Interventions:
Biological: TA-NIC;   Biological: Placebo 
 
 

 
26
Not yet recruiting
Varenicline and Motivational Advice for Smokers With Substance Use Disorders
Conditions:
Smoking Cessation;   Nicotine Dependence 
Interventions:
Drug: Nicotine Replacement Treatment (NRT);   Drug: varenicline;   Behavioral: Behavioral counseling for smoking cessation 
 
 

 
27
Recruiting
Serbian Smoking Reduction/Cessation Trial (2SRT)
Condition:
Cigarette Smoking 
Interventions:
Other: Swedish snus (smokeless tobacco);   Other: Onico 
 
 

 
28
Recruiting
Carotid Plaque Screening Trial in Smokers
Condition:
Smoking 
Interventions:
Device: Carotid ultrasound for plaque screening;   Behavioral: Brief advice for smoking cessation 
 
 

 
29
Recruiting
Evaluating a Telephone-Based Smoking Cessation Program Among People in the Military (The AFIII Study)
Conditions:
Smoking;   Smoking Cessation 
Interventions:
Drug: Nicotine Patch;   Behavioral: Tobacco Quit Line Program 
 
 

 
30
Recruiting
 

 
31
Recruiting
Stop Smoking Therapy for Ontario Patients
Condition:
Smoking 
Interventions:
Drug: nicotine replacement therapy;   Behavioral: behavioural interventions 
 
 

 
32
Recruiting
Literacy and Smoking Risk Communications
Condition:
Smoking 
Interventions:
Behavioral: Focus Group;   Behavioral: Questionnaire 
 
 

 
33
Recruiting
Mood Management Phone Counseling in Smoking Cessation
Condition:
Cigarette Smoking 
Intervention:
Behavioral: Mood Management Phone Counseling for Smoking Cessation 
 
 

 
34
Recruiting
The Effect of Naltrexone and Varenicline on Alcohol-Mediated Smoking Lapse
Condition:
Smoking 
Interventions:
Drug: naltrexone;   Drug: varenicline;   Drug: placebo 
 
 

 
35
Recruiting
Phase I Study: Stop Smoking Therapy for Ontario Patients (STOP)
Condition:
Smoking 
Interventions:
Drug: nicotine replacement;   Behavioral: behavioural intervention 
 
 

 
36
Not yet recruiting
Message Priming and Enrollment in, and Response to, a Smoking Cessation Program: A Pilot Study
Condition:
Smoking Cessation 
Interventions:
Other: Message Prime;   Other: Message Prime 
 
 

 
37
Recruiting
The Effect of Varenicline (Chantix) and Bupropion (Zyban) on Smoking Lapse Behavior
Condition:
Smoking Lapse Behavior 
Interventions:
Drug: varenicline;   Drug: bupropion;   Drug: Placebo 
 
 

 
38
Recruiting
Smoking Cessation Using Motivational Therapy and Varenicline
Conditions:
Smoking;   HIV Infections 
Intervention:
Drug: Varenicline tartrate 
 
 

 
39
Not yet recruiting
Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Smokers With and Without Schizophrenia
Conditions:
Schizophrenia;   Nicotine Dependence 
Interventions:
Behavioral: Smoking Cues;   Behavioral: Neutral Cues 
 
 

 
40
Not yet recruiting
Effectiveness of Free Nicotine Patches, an Online Smoking Cessation Program, and Telephone Counseling at Improving Smoking Cessation Rates
Conditions:
Smoking Cessation;   Tobacco Use Disorder 
Interventions:
Drug: Nicotine patches;   Behavioral: Telephone counseling;   Behavioral: Quitnet.com Web site 
 
 

 
41
Not yet recruiting
Post Marketing Surveillance Study of Champix in Smoking Cessation for Filipino Patients
Condition:
Smoking Cessation 
Intervention:
Drug: Varenicline 
 
 

 
42
Recruiting
Youth Smoking Cessation: Therapy +/- "the Patch"
Conditions:
Teen Smoking;   Smoking and Youth;   Youth and Tobacco 
Intervention:
Drug: NicoDerm CQ (Nicotine replacement therapy) 
 
 

 
43
Recruiting
Smoking Cessation in Subjects With Mild-to-Moderate Chronic Obstructive Pulmonary Disease (COPD).
Condition:
Smoking 
Interventions:
Drug: placebo;   Drug: Varenicline Tartarate 
 
 

 
44
Recruiting
A Study of Varenicline for Prevention of Relapse to Smoking in Patients With Schizophrenia
Conditions:
Schizophrenia;   Schizoaffective Disorder;   Smoking 
Interventions:
Drug: Varenicline;   Drug: Placebo 
 
 

 
45
Not yet recruiting
Reduction of Environmental Tobacco Smoke (ETS) Exposure at Home: the BIBE Study
Condition:
Tobacco Smoke Pollution 
Intervention:
Behavioral: Brief intervention based in clinical practice guide 
 
 

 
46
Recruiting
Endothelial Function and Autonomic Regulation After Short-Term Smoking Cessation: Varenicline Versus Placebo
Condition:
Smoking 
Interventions:
Drug: varenicline;   Drug: placebo 
 
 

 
47
Recruiting
TRIAD Project: Qualitative Study of Adolescent Depression and Smoking
Conditions:
Adolescent Depression;   Adolescent Smoking 
Intervention:
 
 
 

 
48
Recruiting
Zyban as an Effective Smoking Cessation Aid for Patients Following an Acute Coronary Syndrome: The ZESCA Trial
Conditions:
Acute Coronary Syndrome;   Myocardial Infarction;   Smoking 
Interventions:
Drug: Bupropion HCl ER;   Drug: Placebo 
 
 

 
49
Recruiting
Reaching and Treating Lesbian, Gay, Bisexual, and Transgender (LGBT) Cigarette Smokers
Condition:
Cigarette Smoking 
Interventions:
Behavioral: Mail-based Self-help plus Internet-based Smoking Treatment;   Behavioral: Self-Help Manual plus Telephone counseling;   Behavioral: Self-Help Manual;   Behavioral: Self-Help Manual plus Internet-based Intervention plus Telephone Counseling 
 
 

 
50
Recruiting
Clinical Effort Against Secondhand Smoke (CEASE) Program or Standard Care in Helping Parents Stop Smoking
Condition:
Health Status Unknown 
Interventions:
Procedure: counseling;   Procedure: educational intervention;   Procedure: laboratory biomarker analysis;   Procedure: questionnaire administration;   Procedure: smoking cessation intervention;   Procedure: study of high risk factors;   Procedure: survey administration 
 
 
51
Recruiting
Hypnosis for Smoking Relapse Prevention
Condition:
Smoking 
Interventions:
Behavioral: behavior relapse prevention counseling;   Other: hypnosis 
 
 

 
52
Recruiting
Gabapentin for Smoking Cessation
Conditions:
Cigarette Smoking;   Tobacco Use 
Intervention:
Drug: gabapentin 
 
 

 
53
Not yet recruiting
A Novel Treatment to Boost Quit Attempts and Cessation Among Unmotivated Smokers
Conditions:
Smoking;   Smoking Cessation 
Interventions:
Other: Practice Quit Attempt plus nicotine lozenge;   Behavioral: Practice Quit Attempt only 
 
 

 
54
Recruiting
Incentive-Based Smoking Cessation for Methadone Patients
Condition:
Cigarette Smoking Among Patients Currently Receiving Methadone or Buprenorphine Treatment for Opioid Dependence 
Intervention:
Behavioral: incentive-based contingency management 
 
 

 
55
Recruiting
Anxiety Sensitivity Program for Smoking Cessation
Condition:
Smoking Cessation 
Intervention:
Behavioral: Anxiety Sensitivity Program for Smoking Cessation 
 
 

 
56
Recruiting
Smoking Cessation With Smokeless Tobacco, Nicotine Tablets and Nicotine Patches
Condition:
Tobacco Dependence 
Interventions:
Drug: Smokeless tobacco (Oliver Twist pellets);   Behavioral: smoking cessation counseling 
 
 

 
57
Not yet recruiting
Use of Varenicline for 4-Weeks Prior to Quitting
Conditions:
Tobacco Dependence;   Smoking Cessation 
Interventions:
Drug: Varenicline;   Drug: Placebo 
 
 

 
58
Recruiting
Varenicline Observational Investigation In The Cessation of Smoking
Condition:
Smoking Cessation 
Intervention:
Drug: Varenicline 
 
 

 
59
Recruiting
 

 
60
Not yet recruiting
Yoga for Women Attempting Smoking Cessation
Condition:
Smoking 
Interventions:
Behavioral: yoga;   Behavioral: cognitive therapy 
 
 

 
61
Not yet recruiting
Exercise, Smoking Cessation and Adolescents
Condition:
Smoking 
Interventions:
Behavioral: Cognitive-behavioral treatment;   Behavioral: Exercise 
 
 

 
62
Recruiting
ADHD Smoking Cessation Study
Conditions:
Attention Deficit Hyperactivity Disorder;   Nicotine Dependence 
Interventions:
Drug: Lis-dexamphetamine (LDX; Vyvanse) and Transdermal Nicotine Patch;   Drug: Placebo and transdermal nicotine patch 
 
 

 
63
Recruiting
Baclofen Effects on Smoking Urge and Withdrawal
Conditions:
Nicotine Use Disorder;   Nicotine Dependence;   Smoking;   Tobacco Use Disorder 
Intervention:
Drug: Baclofen 
 
 

 
64
Recruiting
Behavioral Exercise Intervention for Smoking Cessation
Condition:
Nicotine Dependence 
Interventions:
Behavioral: aerobic exercise;   Behavioral: Health Education Control 
 
 

 
65
Recruiting
NICU Asthma Education and Secondhand Smoke Reduction Study
Condition:
Respiratory Illness 
Interventions:
Behavioral: Secondhand Smoke Reduction, Smoking Cessation;   Behavioral: Asthma Education with Secondhand Smoke Reduction 
 
 

 
66
Recruiting
Nicotine Patch Pretreatment for Smoking Cessation in PTSD
Conditions:
Stress Disorders, Posttraumatic;   Tobacco Use Disorder 
Interventions:
Drug: Nicotine;   Behavioral: Cognitive Behavioral Therapy for Smoking Cessation;   Drug: Bupropion SR 
 
 

 
67
Recruiting
Longitudinal Care: Smoking Reduction to Aid Cessation
Condition:
Chronic Diseases 
Intervention:
Behavioral: smoking cessation 
 
 

 
68
Not yet recruiting
Responses Induced by Smoking in Individuals Being Susceptible and Non-Susceptible for Development of COPD
Condition:
Chronic Obstructive Pulmonary Disease 
Intervention:
 
 
 

 
69
Recruiting
Phase II Study to Evaluate the Effectiveness of EVT 302 in Smoking Cessation.
Condition:
Smoking Cessation 
Interventions:
Drug: EVT 302;   Drug: Placebo;   Drug: EVT 302 plus open label Nicotine replacement;   Drug: Placebo plus open label Nicotine Replacement 
 
 

 
70
Recruiting
Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban
Conditions:
Insomnia;   Nicotine Dependence 
Interventions:
Drug: Lunesta (Eszopiclone);   Drug: Zyban (bupropion) 
 
 

 
71
Recruiting
Concurrent Nicotine Patch / Denicotinized Cigarette Therapy for Smoking Cessation II
Condition:
Cigarette Smoking 
Intervention:
Drug: Nicotine Patch 
 
 

 
72
Recruiting
Effectiveness of GW468816, an NMDA Glycine Site Antagonist, for Prevention of Relapse to Smoking
Condition:
Nicotine Dependence 
Intervention:
Drug: GW468816 or Placebo Comparator 
 
 

 
73
Not yet recruiting
Safety Study of Varenicline in Smoking Cessation for Patients Post-Acute Coronary Syndrome
Condition:
Acute Coronary Syndrome 
Interventions:
Drug: varenicline;   Other: placebo 
 
 

 
74
Recruiting
Interactive Voice Response Telephone Technology for the Treatment of Smoking in Patients With Heart Disease
Condition:
Coronary Artery Disease 
Interventions:
Behavioral: Interactive Voice Response;   Behavioral: Usual care 
 
 

 
75
Recruiting
Smoking Relapse Prevention in Schizophrenia
Conditions:
Schizophrenia;   Schizoaffective Disorder;   Smokers 
Interventions:
Drug: bupropion;   Drug: transdermal nicotine patch;   Drug: short-acting nicotine replacement therapy 
 
 

 
76
Recruiting
Smoking Cessation Intervention After Stroke or Transient Ischaemic Attack.
Conditions:
Stroke;   Transient Ischemic Attack 
Intervention:
Behavioral: Smoking cessation 
 
 

 
77
Not yet recruiting
Telephone Care Coordination for Smokers in VA Mental Health Clinics
Condition:
Smoking 
Interventions:
Other: Telephone Care Coordination;   Other: Telephone Care Coordination with state Quitline 
 
 

 
78
Recruiting
Prolonged Smoking Cessation Using Prescription Step Care
Condition:
Tobacco Dependence 
Intervention:
Behavioral: Smoking Cessation Intervention 
 
 

 
79
Not yet recruiting
Proactive Tobacco Treatment for Veterans
Conditions:
Smoking Cessation;   Smoking Tobacco 
Intervention:
Behavioral: Proactive Outreach with choice of telephone or in-person smoking cessation services 
 
 

 
80
Recruiting
Implementation of an Evidence Based Smoking Cessation Strategy (SMOCC) for Patients With COPD in Primary Care
Condition:
COPD 
Intervention:
Behavioral: Implementation of a combined smoking cessation strategy 
 
 

 
81
Not yet recruiting
Role of Cigarette Smoking in Regulating Allergen-Induced Early and Late Responses in Mild Asthmatics
Condition:
Asthma 
Interventions:
Procedure: Allergen Challenge;   Other: Allergen Challenge 
 
 

 
82
Recruiting
Prevention of Cigarette Smoking in Attention Deficit Hyperactivity Disorder (ADHD) Youth With Concerta
Condition:
ADHD 
Intervention:
Drug: methylphenidate HCl (Concerta) 
 
 

 
83
Recruiting
Study of Nicotine Patch in Pregnancy (SNIPP)
Condition:
Smoking 
Intervention:
Drug: nicotine versus placebo 
 
 

 
84
Recruiting
Quetiapine Decreases Smoking in Patients With Chronic Schizophrenia
Condition:
Smoking Behavior in Schizophrenia 
Intervention:
Drug: Quetiapine 
 
 

 
85
Recruiting
Varenicline for Cigarette Smoking in Schizophrenia - Efficacy and Predictors
Conditions:
Schizophrenia;   Cigarette Smoking 
Interventions:
Drug: Varenicline;   Drug: Placebo for varenicline 
 
 

 
86
Recruiting
Neural Inhibition as a Mechanism of Nicotine Dependence Among Persons With Schizophrenia
Conditions:
Smoking;   Nicotine Dependence;   Schizophrenia;   Schizophreniform Disorders;   Schizoaffective Disorder;   Psychosis 
Interventions:
Drug: Nicotine patch;   Other: placebo;   Behavioral: smoking cessation group therapy 
 
 

 
87
Recruiting
Treatment With Mecamylamine in Smoking and Non-Smoking Alcohol Dependent Patients
Condition:
Alcoholism 
Intervention:
Drug: mecamylamine 
 
 

 
88
Recruiting
A Randomized Controlled Trial on Smoking Cessation and Adherence Intervention on Patients With Erectile Dysfunction
Condition:
Smoking Cessation 
Interventions:
Procedure: adherence intervention;   Procedure: intervention without adherence advice;   Procedure: control 
 
 

 
89
Recruiting
Evaluating the Effects of Supplemental Vitamin C on Infant Lung Function in Pregnant Smoking Women
Conditions:
Pregnancy;   Smoking 
Interventions:
Other: Placebo;   Dietary Supplement: Vitamin C 
 
 

 
90
Recruiting
Assessment of a Teachable Moment for Smoking Cessation
Condition:
Nicotine Dependence 
Intervention:
Drug: Transdermal nicotine patch 
 
 

 
91
Recruiting
Increasing Contingency Management Success in Smoking Cessation
Condition:
Smoking 
Intervention:
Behavioral: Contingency Management 
 
 

 
92
Recruiting
Varenicline Effects on Cue Reactivity and Smoking Reward/Reinforcement
Condition:
Lung 
Interventions:
Drug: varenicline;   Drug: placebo 
 
 

 
93
Not yet recruiting
 

 
94
Recruiting
Testing Methylphenidate for Smoking Abstinence
Condition:
Smoking 
Intervention:
Drug: Methylphenidate 
 
 

 
95
Recruiting
Reducing Ethnic Health Disparities: Motivating HIV+ Latinos to Quit Smoking
Conditions:
Tobacco Dependence;   HIV Infections 
Interventions:
Behavioral: Standard Care Intervention (SCI);   Behavioral: Culturally Tailored Intervention (CTI) 
 
 

 
96
Recruiting
Smoking Cessation Study for Patients With Schizophrenia or Schizoaffective Disorder
Conditions:
Schizophrenic Disorders;   Schizoaffective Disorders;   Smoking 
Interventions:
Drug: placebo;   Drug: varenicline (CP-526,555) 
 
 

 
97
Not yet recruiting
ASIA CHOICES CHampix Observational Investigation in the CEssation of Smoking
Condition:
Smoking Cessation 
Intervention:
Drug: varenicline 
 
 

 
98
Recruiting
Curbing Tobacco Use in Suburban and Rural Schools
Condition:
Epidemiology 
Interventions:
Behavioral: Smoking Prevention Program;   Behavioral: Focus Group 
 
 

 
99
Recruiting
Assessment of Safety and Efficacy of Varenicline in Patients That Wish to Stop Smoking
Condition:
Smoking Cessation 
Interventions:
Drug: varenicline tartrate (CP-526, 555-18);   Drug: Placebo 
 
 

 
100
Recruiting
Impact of Smoking Cessation on Sleep - 5
Conditions:
Tobacco Use Cessation;   Sleep Disorders 
Interventions:
Drug: Bupropion;   Drug: Transdermal Nicotine Patch;   Drug: Placebo Bupropion;   Drug: Placebo transdermal nicotine patch 
 
 

 
101
Recruiting
Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking
Conditions:
Bladder Cancer;   Cancer-Related Problem/Condition;   Cervical Cancer;   Esophageal Cancer;   Gastric Cancer;   Head and Neck Cancer;   Kidney Cancer;   Leukemia;   Liver Cancer;   Lung Cancer;   Pancreatic Cancer 
Interventions:
Drug: bupropion hydrochloride;   Procedure: counseling;   Procedure: educational intervention;   Procedure: gene expression analysis;   Procedure: laboratory biomarker analysis;   Procedure: liquid chromatography;   Procedure: mass spectrometry;   Procedure: polymerase chain reaction;   Procedure: polymorphism analysis;   Procedure: psychosocial assessment and care;   Procedure: questionnaire administration;   Procedure: smoking cessation intervention;   Procedure: study of socioeconomic and demographic variables 
 
 

 
102
Recruiting
Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking
Conditions:
Bladder Cancer;   Cancer-Related Problem/Condition;   Cervical Cancer;   Esophageal Cancer;   Gastric Cancer;   Head and Neck Cancer;   Kidney Cancer;   Leukemia;   Liver Cancer;   Lung Cancer;   Pancreatic Cancer 
Interventions:
Drug: nicotine;   Procedure: compliance monitoring;   Procedure: counseling;   Procedure: psychosocial assessment and care;   Procedure: smoking cessation intervention 
 
 

 
103
Recruiting
Contingency Management for Smoking Cessation Among Veterans With Psychotic Disorders
Conditions:
Nicotine Dependence;   Psychotic Disorders 
Interventions:
Behavioral: Contingency Management;   Behavioral: Reward 
 
 

 
104
Not yet recruiting
S-Adenosyl-L-Methionine (SAMe) for Smoking Abstinence
Condition:
Smokers 
Interventions:
Drug: S-Adenosyl-L-Methionine;   Drug: S-Adenosyl-L-Methionine;   Other: placebo 
 
 

 
105
Recruiting
Smoking Cessation for HIV/AIDS Patients
Condition:
Human Immunodeficiency Virus 
Interventions:
Behavioral: Cell Phone Intervention;   Other: Recommended Standard of Care 
 
 

 
106
Recruiting
 

 
107
Recruiting
Smoking Abstinence and Response to Smoking Cues
Condition:
Tobacco Smoking 
Intervention:
 
 
 

 
108
Not yet recruiting
Web-Delivered Provider Intervention for Tobacco Control
Condition:
Smoking Cessation 
Interventions:
Behavioral: Decide2Quit;   Behavioral: Smoking Coach 
 
 

 
109
Recruiting
High-Frequency Repetitive Transcranial Magnetic Stimulation Assists In Smoking Cessation
Condition:
Heavy Smoking 
Intervention:
Device: Transcranial Magnetic Stimulation 10Hz 
 
 

 
110
Recruiting
Targeted Interventions for Weight-Concerned Smokers
Condition:
Nicotine Dependence 
Interventions:
Drug: Naltrexone;   Drug: Transdermal nicotine replacement;   Behavioral: Behavioral counseling 
 
 

 
111
Recruiting
Genetic Differences in Limbic Activation Associated With Nicotine Withdrawal
Condition:
Smoking 
Intervention:
Other: Functional Magnetic Resonance Imaging (fMRI) 
 
 

 
112
Recruiting
Effect of Using a Structured Tobacco Cessation Education Program
Condition:
Secondhand Smoke Exposure 
Intervention:
Behavioral: Counseling 
 
 

 
113
Recruiting
Tobacco Smoke and Lead Exposure During Pregnancy
Conditions:
Lead Exposure in Pregnant Women;   Tobacco Smoke Exposure Pregnant Women 
Intervention:
 
 
 

 
114
Not yet recruiting
Neural and Physiologic Correlates of Mental Stress and Cigarette Craving in Patients at Risk for Heart Disease
Condition:
Smoking 
Interventions:
Behavioral: Standard Cognitive Therapy;   Behavioral: Mindfulness Based Cognitive Therapy 
 
 

 
115
Recruiting
Varenicline Effects In Schizophrenic Smokers
Conditions:
Schizophrenia;   Tobocco Use Disorder;   Nicotine Dependance 
Intervention:
Drug: Varenicline 
 
 

 
116
Recruiting
Family-Supported Smoking Cessation for Chronically Ill Veterans
Conditions:
Chronic Disease;   Neoplasm;   Cardiovascular Disease 
Interventions:
Behavioral: Family-supported;   Behavioral: Standard Telephone counseling 
 
 

 
117
Recruiting
How Smoking Causes COPD: Examination of Immune System Changes
Condition:
Chronic Obstructive Pulmonary Disease 
Intervention:
 
 
 

 
118
Recruiting
Improving Medication Compliance and Smoking Cessation Treatment Outcomes for African American Smokers
Condition:
Smokers 
Interventions:
Drug: Chantix;   Other: Chantix and Induction Support Counseling 
 
 

 
119
Not yet recruiting
Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine
Condition:
Tobacco Use Disorder 
Interventions:
Other: Oral tobacco;   Drug: Nicotine replacement 
 
 

 
120
Not yet recruiting
A Study to Evaluate the Safety and Efficacy of Three Doses of a Controlled Release Formulation of Varenicline for Smoking Cessation
Condition:
Smoking Cessation 
Interventions:
Drug: Varenicline Controlled Release 1.2 mg;   Drug: Varenicline Controlled Release 1.8 mg;   Drug: Varenicline Controlled Release 2.4 mg;   Drug: Varenicline Immediate Release 1 mg;   Drug: Placebo 
 
 

 
121
Recruiting
Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study
Condition:
Tobacco Dependence 
Interventions:
Drug: Placebo;   Drug: topiramate;   Drug: topiramate plus nicotine patch 
 
 

 
122
Recruiting
Combined Treatment for Tobacco and Alcohol Use
Condition:
Smoking Cessation 
Interventions:
Behavioral: Questionnaires;   Behavioral: Motivational Relapse Prevention Counseling;   Behavioral: Motivational Relapse Prevention Plus Alcohol Risk Reduction Counseling 
 
 

 
123
Recruiting
GABA (Gamma Amino Butyric Acid) Medication for Tobacco
Condition:
Nicotine Dependence 
Interventions:
Drug: pregabalin;   Other: cigarettes 
 
 

 
124
Recruiting
Prevention of Environmental Tobacco Smoke Exposure in Children 0-12 Months Old
Condition:
Environmental Tobacco Smoke (ETS) 
Intervention:
Behavioral: Counseling 
 
 

 
125
Recruiting
The Pharmacogenetic Study , Readiness to Change , and Pharmacological Intervention for Smoking Cessation in Schizophrenia
Conditions:
Tobacco Dependence;   Schizophrenia 
Intervention:
Drug: NRT, bupropion 
 
 

 
126
Recruiting
Study of Varencline Effects on Cigarette Smoking Reward and Craving During a Model of Brief Quit Attempt
Condition:
Nicotine Dependence 
Interventions:
Drug: varencline;   Drug: placebo 
 
 

 
127
Recruiting
Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking
Conditions:
Bladder Cancer;   Cancer-Related Problem/Condition;   Cervical Cancer;   Esophageal Cancer;   Gastric Cancer;   Head and Neck Cancer;   Kidney Cancer;   Leukemia;   Liver Cancer;   Lung Cancer;   Pancreatic Cancer 
Interventions:
Drug: nicotine;   Drug: placebo;   Drug: varenicline 
 
 

 
128
Recruiting
Effects of Smoking on Opioid Receptor Binding Using [(11)C]Carfentanil: an Imaging PET Study
Condition:
Substance-Related Discorder 
Interventions:
Drug: Nicotine;   Drug: Carfentanil 
 
 

 
129
Recruiting
Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation
Condition:
Tobacco Use Disorder 
Interventions:
Drug: Bupropion;   Drug: Bupropion + Naltrexone 
 
 

 
130
Recruiting
Measuring Smoking Behavior in People With Schizophrenia and Bipolar Disorder
Conditions:
Schizophrenia;   Bipolar Disorder 
Intervention:
Device: CReSSmicro handheld topography device 
 
 

 
 
132
Recruiting
Oral Cancer Risk Reduction Through Treatment for Tobacco and Alcohol Use
Condition:
Smoking 
Interventions:
Behavioral: Motivational Relapse Prevention (MRP);   Behavioral: Standard Treatment (ST) 
 
 

 
133
Recruiting
Effect of Memantine Versus Bupropion on Smoking Relapse in Nicotine-Dependent Individuals - 3
Condition:
Tobacco Use Disorder 
Intervention:
Drug: Memantine 
 
 

 
134
Recruiting
Do Treatments for Smoking Cessation Affect Alcohol Drinking? Study 2: Do Varenicline (Chantix) and Bupropion (Zyban) Change Alcohol Drinking?
Condition:
Alcohol Drinking 
Interventions:
Drug: varenicline;   Drug: bupropion;   Drug: placebo 
 
 

 
135
Recruiting
Effects of Chronic Smoking on Circulating Endothelial-Derived Microparticle
Condition:
Atherosclerosis 
Intervention:
Behavioral: smoking cessation 
 
 

 
136
Recruiting
Enhancing Motivation To Quit Smoking In Smokers With Serious Mental Illness
Conditions:
Schizophrenia;   Schizoaffective Disorder 
Intervention:
Behavioral: Motivational Interviewing or Psychoeducational Intervention 
 
 

 
137
Recruiting
Strategies to Help Adult ED Patients Quit Smoking
Condition:
Tobacco Use 
Interventions:
Drug: transdermal nicotine patches;   Behavioral: Motivational interview 
 
 

 
138
Recruiting
Menstrual Cycle Effects on Smoking Cessation and Cue Reactivity
Condition:
Nicotine Dependence 
Interventions:
Drug: varenicline;   Device: transdermal nicotine patch 
 
 

 
139
Not yet recruiting
Relapse Prevention Study in Newly Abstinent Smokers
Conditions:
Smoking;   Substance Dependence 
Interventions:
Drug: open label;   Drug: double blind treatment 
 
 

 
140
Not yet recruiting
Topiramate to Aid Smoking Cesstion in Alcohol Dependent Men
Conditions:
Nicotine Dependence;   Alcohol Dependence 
Interventions:
Drug: Topiramate;   Drug: Placebo 
 
 

 
141
Recruiting
Effectiveness of Nicotine Replacement Therapy in Reducing the Risk of Nicotine Exposure in Pregnant Minority Smokers
Conditions:
Smoking;   Pregnancy 
Intervention:
Behavioral: Nicotine Replacement Therapy 
 
 

 
142
Recruiting
Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers
Condition:
Tobacco Use Disorder 
Intervention:
Other: Product Preference 
 
 

 
143
Recruiting
Linking Lives: Building Quality Parent Components for School-Based Health Programs in Middle Schools
Conditions:
Smoking;   Sexual Behavior 
Intervention:
Behavioral: Parent-based tobacco use prevention & sexual risk reduction 
 
 

 
144
Recruiting
Contingent Incentives Plus Bupropion for Smoking in People With Schizophrenia
Conditions:
Schizophrenia and Disorders With Psychotic Features;   Tobacco Use Disorder 
Interventions:
Drug: Bupropion;   Drug: Contingent reinforcement plus placebo;   Drug: non-contingent reinforcement plus bupropion;   Drug: Non-contingent reinforcement plus placebo 
 
 

 
145
Recruiting
Attitudes About Smoking: A Telephone Survey
Condition:
Asthma 
Intervention:
 
 
 

 
146
Not yet recruiting
Parental Education on Passive Smoke Exposure and Respiratory Diseases in Infants
Condition:
Tobacco Smoke Pollution 
Intervention:
Behavioral: Guidance 
 
 

 
147
Not yet recruiting
Treatment to Stop Smoking and Drinking in Preventing Oral Cancer in Smokers in Puerto Rico
Conditions:
Cancer-Related Problem/Condition;   Head and Neck Cancer 
Interventions:
Procedure: counseling;   Procedure: preventive intervention;   Procedure: questionnaire administration;   Procedure: smoking cessation intervention 
 
 

 
148
Not yet recruiting
Varenicline in Bipolar Depressed Patients
Conditions:
Smoking;   Bipolar;   Depression 
Intervention:
Drug: Varenicline 
 
 

 
 
150
Not yet recruiting
Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers
Conditions:
Nicotine Dependence;   Smoking;   Tobacco Use Disorder;   Nicotine Use Disorder 
Intervention:
Drug: Nicotine 
 
 
151
Not yet recruiting
Cardiovascular Effects of Oligomeric Procyanidins (OPCs) in Smokers
Condition:
Smoking 
Interventions:
Dietary Supplement: oligomeric proanthocyanidins (MASQUELIER'S Original OPCs);   Dietary Supplement: Placebo 
 
 

 
152
Not yet recruiting
Smoking Cessation Intervention for Patients Undergoing Lung Surgery
Condition:
Lung Cancer 
Intervention:
Behavioral: CBT 
 
 

 
153
Recruiting
Do Treatments for Smoking Cessation Affect Alcohol Drinking? Study 1: Nicotine Replacement Therapy
Condition:
Alcohol Drinking 
Interventions:
Drug: 21mg transdermal nicotine patch (Nicoderm CQ);   Drug: 1mg nicotine nasal spray;   Drug: placebo nasal spray 
 
 

 
154
Recruiting
Practicing Self-Control Lowers the Risk of Smoking Lapse
Conditions:
Addictions;   Cigarette Smoking 
Intervention:
Behavioral: self-control practice 
 
 

 
155
Recruiting
Reduction of Environmental Tobaacco Smoke (ETS) Exposure In Pediatric Cancer Patients
Condition:
Cancer 
Interventions:
Behavioral: Health Risk and Beahvioral Skills Coaching Sessions;   Behavioral: Telephone Coaching Sessions;   Behavioral: Physician Feedback Letter 
 
 

 
156
Recruiting
Biomarkers of Molecular Risk in Smokers
Condition:
Smoking Cessation 
Interventions:
Behavioral: Vignette, questionnaires and Saliva Samples;   Behavioral: Urine Collection, Smoking cessation treatment 
 
 

 
157
Recruiting
Preventing Weight Gain and Controlling Blood Pressure During Smoking Cessation in Hypertensive Smokers
Conditions:
Cardiovascular Diseases;   Heart Diseases;   Hypertension 
Interventions:
Drug: Nicotine Replacement Therapy;   Behavioral: Diet 
 
 

 
158
Recruiting
Research to Improve Smoke Alarm Functioning and Maintenance
Conditions:
Wounds and Injuries;   Burns 
Intervention:
Behavioral: Fire safety education 
 
 

 
159
Recruiting
Erlotinib and Chemotherapy for Operable Stage IB-IIIA Non-Small Cell Lung Cancer (NSCLC) Patients With Less Than or Equal 15 Pack Year Smoking History
Conditions:
Non Small Cell Lung Cancer;   Lung Cancer 
Intervention:
Drug: pemetrexed, cisplatin and erlotinib before surgery then erlotinib is given to patients after surgery for 2 years 
 
 

 
160
Recruiting
Safety and Tolerability of Varenicline in Schizophrenia (SATOVA)
Conditions:
Schizophrenia;   Schizoaffective;   Psychosis 
Intervention:
Drug: Varenicline 
 
 

 
161
Recruiting
Preoperative Nicotine Lozenges
Condition:
Smoking 
Interventions:
Drug: nicotine lozenge;   Drug: Placebo lozenge 
 
 

 
162
Recruiting
Smoking Cessation for Young Adults Who Binge Drink - 1
Conditions:
Adherence;   Tobacco Use Cessation;   Alcohol & Drug Use;   Nicotine Transdermal System 
Intervention:
Behavioral: Tobacco Use Cessation 
 
 

 
163
Recruiting
Naltrexone and Varenicline: Weight Gain and Tolerability in Cigarette Smokers
Conditions:
Smoking;   Nicotine Dependence 
Interventions:
Drug: Naltrexone;   Drug: Varenicline 
 
 

 
164
Recruiting
Efficacy and Safety of Bupropion for Treatment of Adolescent Smoking
Condition:
Tobacco Dependence 
Intervention:
Drug: Bupropion 
 
 

 
165
Not yet recruiting
To Examine Smoking Behavior of Prisoners - 1
Condition:
 
Intervention:
 
 
 

 
166
Recruiting
Message Framing for Telephone Quitline Callers
Conditions:
Smoking;   Nicotine Dependence 
Interventions:
Behavioral: "Yale coaching";   Behavioral: Standard care 
 
 

 
167
Recruiting
Asian Youth and Tobacco Control Survey
Conditions:
Tobacco Use;   Smoking 
Intervention:
Behavioral: Questionnaire 
 
 

 
168
Recruiting
Group Therapy for Nicotine Dependence
Conditions:
Smoking;   Tobacco Use Cessation 
Intervention:
Behavioral: Mindfulness-Based Addiction Treatment (MBAT) 
 
 

 
169
Recruiting
Improving Smoking Cessation Outcomes in Heavy Drinkers - 1
Condition:
Tobacco Use Disorder 
Intervention:
Behavioral: Behavior Therapy 
 
 

 
170
Not yet recruiting
Tobacco Tactics Website for Veteran Smokers
Condition:
Smoking 
Intervention:
Behavioral: Tobacco Tactics website 
 
 

 
171
Recruiting
Smoking Treatment in HIV Clinical Care Settings
Condition:
Nicotine Dependence 
Interventions:
Behavioral: Internet-based smoking treatment;   Behavioral: Individual Counseling;   Behavioral: self-help 
 
 

 
172
Recruiting
Sequential Use of Fluoxetine for Smokers With Elevated Depressive Symptoms
Conditions:
Major Depressive Disorder;   Nicotine Dependence;   Depression 
Interventions:
Drug: Fluoxetine;   Drug: Dextrose 
 
 

 
173
Recruiting
Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence
Conditions:
Smoking Cessation;   Alcohol-Related Disorders 
Interventions:
Drug: Bupropion;   Drug: placebo 
 
 

 
174
Recruiting
Effect of Progesterone on Smoking Behavior in Male and Female Smokers
Condition:
Tobacco Use Disorder 
Intervention:
Drug: Progesterone 
 
 

 
175
Recruiting
Effects of Low-Dose Naltrexone in Combination With a Range of Smoked Marijuana
Condition:
Marijuana Smoking 
Interventions:
Drug: Naltrexone;   Drug: Smoked marijuana 
 
 

 
176
Recruiting
Neuroimaging Attentional Impairment During Abstinence
Conditions:
Smoking;   Non Smoking 
Intervention:
 
 
 

 
177
Recruiting
The Stress Responses of Fetuses and Infants Whose Mothers Smoked During Pregnancy
Condition:
Effects of Smoking on Infant 
Intervention:
 
 
 

 
178
Recruiting
Family Heart Health Program: Randomized, Controlled Trial
Condition:
Coronary Heart Disease 
Intervention:
Behavioral: 12-week risk reduction program, managed by a Heart Health Educator 
 
 

 
179
Recruiting
The Effect of Smoking on Perception
Condition:
Nicotine Dependence 
Intervention:
 
 
 

 
180
Not yet recruiting
Pre-Clinical Cardiac Dysfunction Among Asymptomatic Hypertensive Patients
Conditions:
Hypertension;   High Blood Pressure;   Ventricular Hypertrophy;   Diastolic Dysfunction;   Systolic Dysfunction 
Interventions:
Behavioral: Exercise;   Behavioral: Exercise;   Behavioral: Weight Loss;   Behavioral: Low Sodium Diet;   Behavioral: Smoking Cessation;   Drug: Pharmaceutical Therapy (no specific therapy; approach guided by the JNC 7 protocol guidelines);   Behavioral: Weight Loss;   Behavioral: Low Sodium Diet;   Behavioral: Smoking Cessation;   Drug: Pharmaceutical Therapy (no specific therapy; approach guided by the JNC 7 protocol guidelines) 
 
 

 
181
Not yet recruiting
Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence
Conditions:
Nicotine Dependence;   Nicotine Withdrawal 
Interventions:
Drug: Bupropion SR;   Drug: Varenicline 
 
 

 
182
Recruiting
Strategies to Reduce Weight Gain in Hypertensive Smokers
Conditions:
Cardiovascular Diseases;   Heart Diseases;   Hypertension;   Obesity 
Interventions:
Behavioral: Weight Reducing Diet;   Behavioral: Exercise;   Behavioral: Smoking Cessation 
 
 

 
183
Recruiting
Gene-Environment Interactions in Rheumatoid Arthritis Autoimmunity Disease Severity
Condition:
Rheumatoid Arthritis 
Intervention:
 
 
 

 
184
Recruiting
Tiotropium for Smoking Asthmatics Study
Condition:
Asthma 
Intervention:
Drug: tiotropium 
 
 

 
185
Recruiting
Effectiveness of Bupropion for Treating Nicotine Dependence in Young People
Conditions:
Tobacco Use Cessation;   Tobacco Use Disorder 
Interventions:
Drug: Bupropion;   Drug: Placebo;   Behavioral: CBT Treatment 
 
 

 
186
Recruiting
Varenicline and Nicotine Interactions in Humans (VA)
Condition:
Smoking Cessation 
Interventions:
Drug: varenicline;   Drug: placebo 
 
 

 
187
Recruiting
The Effects of Rimonabant, on Weight and Metabolic Risk Factors
Conditions:
Schizophrenia;   Schizoaffective Disorder;   Obesity;   Hypertension;   Smoking 
Interventions:
Drug: Rimonabant;   Drug: Placebo 
 
 

 
188
Recruiting
Effect of Paroxetine on Smokers' Cardiovascular Response to Stress - 1
Condition:
Tobacco Use Disorder 
Intervention:
Drug: Paroxetine 
 
 

 
189
Not yet recruiting
Evaluation of the Safety Profile, Quit and Reduction Rate After Nicorette® Gum and Patch Treatment
Condition:
Tobacco Dependence 
Interventions:
Drug: Nicotine Gum;   Drug: Nicotine Patch 
 
 

 
190
Recruiting
A Brain Imaging Study Into Nicotine Induced Dopamine Release in Cigarette Smokers.
Condition:
Tobacco Use Disorder 
Intervention:
Procedure: PET Brain Imaging 
 
 

 
191
Recruiting
Quitline Use in Surgical Patients
Condition:
Tobacco Dependence 
Interventions:
Behavioral: Standard brief advice;   Behavioral: Quitline intervention 
 
 

 
192
Recruiting
Tobacco Use Intervention Among Radiation Oncology Patients
Condition:
Tobacco Use Disorder 
Intervention:
Other: Behavioral and pharmacologic tobacco use intervention 
 
 

 
193
Recruiting
Determinants of Corticosteroid Insensitivity in Smokers With Asthma
Conditions:
Asthma;   Smoking;   Steroid Resistance;   Corticosteroid Insensitivity 
Intervention:
Drug: oral steroid-dexamethasone 
 
 

 
194
Recruiting
Tobacco Use Among Arab American Youth
Condition:
Tobacco Use Disorder 
Intervention:
Behavioral: Modified Project Toward No Tobacco Use 
 
 

 
195
Recruiting
Study of Nicotine Replacement Therapy in Pregnancy
Condition:
Smoking Cessation 
Interventions:
Drug: Nicoderm patches;   Other: Counselling 
 
 

 
196
Recruiting
Opioid and Cannabinoid Pharmacokinetic Interactions
Conditions:
Pain;   Neoplasms 
Intervention:
Drug: Cannabis 
 
 

 
197
Not yet recruiting
Smoking Cessation in Nonunion, Malunion, Osseous Infection
Conditions:
Fracture Nonunion;   Infection 
Intervention:
 
 
 

 
198
Recruiting
The Healthy Options Feasibility Study
Conditions:
Obesity;   Sedentary Lifestyle;   Dyslipidemia;   Hypertension;   Cigarette Smoking;   Diabetes 
Intervention:
Behavioral: CVD risk profile 
 
 

 
199
Recruiting
Assessment of Ventilation-Perfusion Abnormalities in Patients With Stable Smoking-Related Airways Disease
Condition:
Chronic Obstructive Pulmonary Disease 
Interventions:
Drug: salbutamol + ipratropium bromide nebules;   Procedure: ventilation-perfusion scan;   Procedure: lung function assessment 
 
 

 
200
Recruiting
Clinical and Economic Benefits of Cardiovascular Risk Management by a Dietician in Type 2 Diabetes Patients
Condition:
Type 2 Diabetes 
Interventions:
Behavioral: diet;   Behavioral: physical activity;   Behavioral: Smoking cessation;   Procedure: Drugs prescriptions