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Asthma

Clinical Trials  |  Add a link  |  Regulations  |  Discussion Board  |  Ask the Nurse | Last Update January 1st. 2009  |  About FDA.COM  | Media Kit

What Is Asthma?

Asthma (AZ-ma) is a chronic (long-term) lung disease that inflames and narrows the airways. Asthma causes recurring periods of wheezing (a whistling sound when you breathe), chest tightness, shortness of breath, and coughing. The coughing often occurs at night or early in the morning.

Asthma affects people of all ages, but it most often starts in childhood. In the United States, more than 22 million people are known to have asthma. Nearly 6 million of these people are children.

Overview

The airways are tubes that carry air into and out of your lungs. People who have asthma have inflamed airways. This makes the airways swollen and very sensitive. They tend to react strongly to certain substances that are breathed in.

When the airways react, the muscles around them tighten. This causes the airways to narrow, and less air flows to your lungs. The swelling also can worsen, making the airways even narrower. Cells in the airways may make more mucus than normal. Mucus is a sticky, thick liquid that can further narrow your airways.

This chain reaction can result in asthma symptoms. Symptoms can happen each time the airways are irritated.

Asthma

Figure A shows the location of the lungs and airways in the body. Figure B shows a cross-section of a normal airway. Figure C shows a cross-section of an airway during asthma symptoms.

Figure A shows the location of the lungs and airways in the body. Figure B shows a cross-section of a normal airway. Figure C shows a cross-section of an airway during asthma symptoms.

Sometimes symptoms are mild and go away on their own or after minimal treatment with an asthma medicine. At other times, symptoms continue to get worse. When symptoms get more intense and/or additional symptoms appear, this is an asthma attack. Asthma attacks also are called flareups or exacerbations.

It's important to treat symptoms when you first notice them. This will help prevent the symptoms from worsening and causing a severe asthma attack. Severe asthma attacks may require emergency care, and they can cause death.

Outlook

Asthma can't be cured. Even when you feel fine, you still have the disease and it can flare up at any time.

But with today's knowledge and treatments, most people who have asthma are able to manage the disease. They have few, if any, symptoms. They can live normal, active lives and sleep through the night without interruption from asthma.

For successful, comprehensive, and ongoing treatment, take an active role in managing your disease. Build strong partnerships with your doctor and other clinicians on your health care team.

 

Reference Links - Add a link

 

Clinical Trials - Add a clinical trial

 top
1
Recruiting
Reducing Asthma Disparities by Improving Provider-Patient Communication
Condition:
Asthma 
Intervention:
Device: Asthma Control and Communication Instrument 
 
 

 
2
Not yet recruiting
Pilot Study of Pioglitazone for the Treatment of Moderate to Severe Asthma in Obese Asthmatics (Glitz Asthma)
Condition:
Asthma 
Interventions:
Drug: Pioglitazone;   Drug: Placebo 
 
 

 
3
Not yet recruiting
Pilot Study of Pioglitazone for the Treatment of Moderate to Severe Asthma in Obese Asthmatics
Condition:
Asthma 
Interventions:
Drug: pioglitazone;   Drug: placebo 
 
 

 
4
Recruiting
Comparing Asthma Action Plans for Pediatric Asthma
Condition:
Asthma 
Intervention:
Device: Pictorial asthma action plan 
 
 

 
5
Recruiting
Optimization of Asthma Treatment Through Exhaled NO for Increased Asthma-Related Quality of Life (NOAK)
Condition:
Allergic Asthma 
Intervention:
Device: Use of exhaled NO as a guide to regulate asthma treatment 
 
 

 
6
Recruiting
Omalizumab Use and Asthma-Related Quality of Life in Patients With Severe Persistent Allergic Asthma
Condition:
Asthma 
Interventions:
Drug: Omalizumab;   Drug: conventional therapy 
 
 

 
7
Recruiting
Asthma Patient Education in the Emergency Room
Condition:
Asthma 
Interventions:
Behavioral: Asthma Education in Adults;   Behavioral: Standard Emergency Room Asthma Education 
 
 

 
8
Recruiting
Childhood Asthma Research and Education (CARE) Network Trial - Treating Children to Prevent Exacerbations of Asthma (TREXA)
Condition:
Asthma 
Interventions:
Drug: Beclomethasone dipropionate;   Drug: Beclomethasone dipropionate;   Drug: Albuterol sulfate 
 
 

 
9
Not yet recruiting
A Reminder System for Paper-Based Asthma Guidelines in the Pediatric Emergency Department
Conditions:
Asthma;   Medical Informatics 
Intervention:
Other: Paper-based asthma flow diagram 
 
 

 
10
Recruiting
 

 
 
12
Recruiting
Effectiveness of Chinese Herbal Therapy for Asthma
Condition:
Asthma 
Interventions:
Drug: ASHMI;   Drug: ASHMI;   Drug: Placebo 
 
 

 
13
Recruiting
Family Approach to Managing Asthma in Early Teens
Conditions:
Asthma;   Lung Diseases 
Interventions:
Behavioral: Asthma: It's a Family Affair!;   Behavioral: Asthma and Stress Comparator 
 
 

 
14
Recruiting
Problem-Solving Skills Training to Improve Care for Children With Asthma
Condition:
Asthma 
Interventions:
Behavioral: Problem solving skills training and asthma care coordination;   Behavioral: Asthma care coordination alone;   Behavioral: Wait-list control 
 
 

 
15
Not yet recruiting
 

 
16
Recruiting
Asthma Clinical Research Network (ACRN) Trial - Best Adjustment Strategy for Asthma in Long Term (BASALT)
Condition:
Asthma 
Intervention:
Drug: Beclomethasone dipropionate 
 
 

 
17
Recruiting
Tailored Asthma Management for Urban Teens
Condition:
Asthma 
Interventions:
Behavioral: Tailored Web-based Asthma Management;   Behavioral: Generic web-based asthma education 
 
 

 
18
Recruiting
National Survey on Asthma
Condition:
Asthma 
Intervention:
 
 
 

 
19
Recruiting
AZISAST Study: AZIthromycin in Severe ASThma Study
Condition:
Asthma 
Interventions:
Drug: Azithromycin 250 mg;   Drug: Placebo 
 
 

 
20
Recruiting
AZMATICS: AZithroMycin/Asthma Trial In Community Settings
Condition:
Asthma 
Interventions:
Drug: Azithromycin;   Drug: Placebo 
 
 

 
21
Recruiting
Intervention for Improving Asthma Care for Minority Children in Head Start
Conditions:
Asthma;   Lung Diseases 
Interventions:
Behavioral: Facilitated Asthma Communication Intervention (FACI);   Behavioral: Breathmobile intervention 
 
 

 
22
Recruiting
Computer-Based Decision Support in Managing Asthma in Primary Care
Condition:
Asthma 
Intervention:
Device: computer-based decision support for asthma management 
 
 

 
23
Recruiting
Tiotropium for Smoking Asthmatics Study
Condition:
Asthma 
Intervention:
Drug: tiotropium 
 
 

 
24
Recruiting
Fish Oil Supplementation During Pregnancy for Prevention of Asthma, Eczema and Allergies in Childhood
Conditions:
Asthma;   Eczema;   Allergy 
Interventions:
Dietary Supplement: n-3 fatty acid;   Dietary Supplement: olive oil 
 
 

 
25
Recruiting
p38 Mitogen−Activated Protein Kinase (MAPK) and Steroid Insensitivity in Asthma
Condition:
Asthma 
Intervention:
Other: Fiberoptic bronchoscopy; blood test 
 
 

 
26
Recruiting
A Study to Evaluate the Efficacy of Xolair in Atopic Asthmatics
Condition:
Asthma 
Interventions:
Drug: omalizumab;   Drug: placebo 
 
 

 
27
Recruiting
Effect of Statins on Asthma Control in Smokers With Asthma + Pilot Study of Effect of Statins on Lung Function in COPD
Conditions:
Asthma;   COPD;   Smoking 
Interventions:
Drug: Atorvastatin;   Drug: atorvastatin;   Drug: matched placebo 
 
 

 
28
Recruiting
Effects of L-Arginine Supplementation in Adults With Moderate to Severe Asthma
Condition:
Asthma 
Intervention:
Drug: L-Arginine 
 
 

 
29
Recruiting
Oral Contraceptives and Asthma Control
Condition:
Asthma 
Intervention:
 
 
 

 
30
Not yet recruiting
Pioglitazone Hydrochloride (Actos® (Registered Trademark)) to Treat Asthma
Conditions:
Asthma;   Airway Inflammation;   Airflow Obstruction;   Airway Hyperactivity 
Intervention:
Drug: Pioglitazone Hydrochloride 
 
 

 
31
Recruiting
Clinical Trial of the Efficacy and Safety of Beclomethasone Dipropionate Plus Formoterol vs Fluticasone Propionate Plus Salmeterol in the 6 Months Step Down Treatment of Asthma
Condition:
Asthma 
Interventions:
Drug: Beclomethasone plus formoterol fixed combination;   Drug: Fluticasone plus salmeterol fixed combination 
 
 

 
32
Not yet recruiting
Fenzian Asthma Multicenter Outpatient Study
Condition:
Asthma 
Interventions:
Device: Fenzian Device;   Device: Sham Device 
 
 

 
33
Recruiting
Determinants of Corticosteroid Insensitivity in Smokers With Asthma
Conditions:
Asthma;   Smoking;   Steroid Resistance;   Corticosteroid Insensitivity 
Intervention:
Drug: oral steroid-dexamethasone 
 
 

 
34
Recruiting
Inhaled Corticosteroids After a Pediatric Emergency Visit for Asthma
Condition:
Asthma 
Intervention:
Drug: Pulmicort or Flovent 
 
 

 
35
Recruiting
Effect of Anti-IgE in Non-Allergic Asthma
Condition:
Asthma 
Intervention:
Drug: omalizumab 
 
 

 
 
37
Recruiting
Should Non-Eosinophilic Asthmatic Subjects be Treated With Inhaled Corticosteroids?
Condition:
Non-Eosinophilic Asthma 
Interventions:
Drug: Placebo;   Drug: Fluticasone 
 
 

 
38
Recruiting
Menstrual Differences in Airway Inflammation in Asthma
Condition:
Asthma 
Intervention:
 
 
 

 
39
Recruiting
Involving Community Pharmacies in Improving Asthma Outcomes in an Urban Pediatric Population
Condition:
Asthma 
Intervention:
Behavioral: Enhanced Pharmacy Care 
 
 

 
40
Recruiting
Can Education for South Asians With Asthma and Their Clinicians Reduce Unscheduled Care? A Randomised Trial
Condition:
Asthma 
Interventions:
Behavioral: PACE (Professional Asthma Care Education);   Behavioral: Lay Led Expert Patient Programme 
 
 

 
41
Recruiting
Use of Montelukast to Treat Children With Mild to Moderate Acute Asthma
Condition:
Asthma, Bronchial 
Intervention:
Drug: Montelukast (dr8g) 
 
 

 
42
Recruiting
Inflammatory, Functional and Image Composite Measure to Define Asthma Control
Condition:
Asthma 
Intervention:
Drug: prednisone 
 
 

 
43
Recruiting
 

 
44
Not yet recruiting
 

 
45
Recruiting
Effect of Montelukast on Experimentally-Induced RV16 Infection in Asthma
Condition:
Asthma 
Interventions:
Drug: montelukast;   Drug: placebo 
 
 

 
46
Recruiting
Leukotriene Receptor Antagonists or Steroids in Pre-School Asthma
Condition:
Asthma 
Interventions:
Drug: Intake of Montelukast;   Drug: Intake of Fluticasone 
 
 

 
47
Recruiting
Evaluating Long Acting Beta Agonists Used to Treat Asthma Among Those With Either Arg/Arg or Gly/Gly Genotypes
Condition:
Asthma 
Intervention:
Drug: fluticasone with salmeterol or fluticasone alone 
 
 

 
48
Not yet recruiting
A Safety, Efficacy and Tolerability Study in Pediatric Subjects With Asthma
Condition:
Asthma 
Interventions:
Drug: Levalbuterol;   Drug: Levalbuterol UDV TID;   Drug: Placebo 
 
 

 
49
Not yet recruiting
Treatment of Bronchial Asthma With Borage and Echium Seed Oils
Condition:
Bronchial Asthma 
Interventions:
Dietary Supplement: Borage Seed Oil and Echium Seed Oil;   Dietary Supplement: Corn Oil