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Acne

Clinical Trials  |  Add a link  |  Regulations  |  Discussion Board  |  Ask the Nurse | Last Update January 1st. 2009  |  About FDA.COM  | Media Kit

What Is Acne?
Fast Facts: An Easy-to-Read Series of Publications for the Public

Acne is a disease that affects the skin's oil glands. The small holes in your skin (pores) connect to oil glands under the skin. These glands make an oily substance called sebum. The pores connect to the glands by a canal called a follicle. Inside the follicles, oil carries dead skin cells to the surface of the skin. A thin hair also grows through the follicle and out to the skin. When the follicle of a skin gland clogs up, a pimple grows.

Most pimples are found on the face, neck, back, chest, and shoulders. Acne is not a serious health threat but, it can cause scars.

How Does Acne Develop?
Who Gets Acne?
What Causes Acne?
How Is Acne Treated?
How Should People With Acne Care for Their Skin?
What Things Can Make Acne Worse?
What Are Some Myths About the Causes of Acne?
What Research Is Being Done on Acne?

How Does Acne Develop?

Sometimes, the hair, sebum, and skin cells clump together into a plug. The bacteria in the plug causes swelling. Then when the plug starts to break down, a pimple grows.

There are many types of pimples. The most common types are:

  • Whiteheads. These are pimples that stay under the surface of the skin.
  • Blackheads. These pimples rise to the skin's surface and look black. The black color is not from dirt.
  • Papules. These are small pink bumps that can be tender.
  • Pustules. These pimples are red at the bottom and have pus on top.
  • Nodules. These are large, painful, solid pimples that are deep in the skin.
  • Cysts. These deep, painful, pus-filled pimples can cause scars.

Who Gets Acne?

Acne is the most common skin disease. People of all races and ages get acne. But it is most common in teenagers and young adults. An estimated 80 percent of all people between the ages of 11 and 30 have acne outbreaks at some point. Some people in their forties and fifties still get acne.

What Causes Acne?

The cause of acne is unknown. Doctors think certain factors might cause it:

  • The hormone increase in teenage years (this can cause the oil glands to plug up more often)
  • Hormone changes during pregnancy
  • Starting or stopping birth control pills
  • Heredity (if your parents had acne, you might get it, too)
  • Some types of medicine
  • Greasy makeup.

How Is Acne Treated?

Acne is treated by doctors who work with skin problems (dermatologists). Treatment tries to:

  • Heal pimples
  • Stop new pimples from forming
  • Prevent scarring
  • Help reduce the embarrassment of having acne.

Early treatment is the best way to prevent scars. Your doctor may suggest over-the-counter (OTC) or prescription drugs. Some acne medicines are put right on the skin. Other medicines are pills that you swallow. The doctor may tell you to use more than one medicine.

How Should People With Acne Care for Their Skin?

Here are some ways to care for skin if you have acne:

  • Clean skin gently. Use a mild cleanser in the morning, evening, and after heavy workouts. Scrubbing the skin does not stop acne. It can even make the problem worse.
  • Try not to touch your skin. People who squeeze, pinch, or pick their pimples can get scars or dark spots on their skin.
  • Shave carefully. If you shave, you can try both electric and safety razors to see which works best. With safety razors, use a sharp blade. Also, it helps to soften your beard with soap and water before putting on shaving cream. Shave lightly and only when you have to.
  • Stay out of the sun. Many acne medicines can make people more likely to sunburn. Being in the sun a lot can also make skin wrinkle and raise the risk of skin cancer.
  • Choose makeup carefully. All makeup should be oil free. Look for the word “noncomedogenic” on the label. This means that the makeup will not clog up your pores. But some people still get acne even if they use these products.

What Things Can Make Acne Worse?

Some things can make acne worse:

  • Changing hormone levels in teenage girls and adult women 2 to 7 days before their period starts
  • Pressure from bike helmets, backpacks, or tight collars
  • Pollution and high humidity
  • Squeezing or picking at pimples
  • Hard scrubbing of the skin.

What Are Some Myths About the Causes of Acne?

There are many myths about what causes acne. Dirty skin and stress do not cause acne. Also, chocolate and greasy foods do not cause acne in most people.

What Research Is Being Done on Acne?

Scientists are looking at new ways to treat acne. They are:

  • Working on new drugs to treat acne
  • Looking at ways to prevent plugs
  • Looking at ways to stop the hormone testosterone from causing acne.

For More Information on Acne and Other Related Conditions:

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Information Clearinghouse
National Institutes of Health

1 AMS Circle
Bethesda,  MD 20892-3675
Phone: 301-495-4484
Toll Free: 877-22-NIAMS (226-4267)
TTY: 301–565–2966
Fax: 301-718-6366
Email: NIAMSinfo@mail.nih.gov
Website: http://www.niams.nih.gov

 

 

Stridex

Reference Links - Add a link

 

Clinical Trials - Add a clinical trial

 top
1
Recruiting
Comparison Study of Topical Acne Regimens
Condition:
Acne 
Interventions:
Drug: Acne Free;   Drug: Proactiv 
 
 

 
2
Recruiting
NdYag Laser for Acne Keloidalis Nuchae
Conditions:
Acne Keloidalis Nuchae;   NdYag Laser;   AKN;   Acne Keloidalis;   AK;   Dermatitis Papillaris Capillitii;   Folliculitis Keloidalis Nuchae;   Sycosis Nuchae;   Acne Keloid;   Keloidal Folliculitis;   Lichen Keloidalis Nuchae;   Folliculitis Nuchae Scleroticans;   Sycosis Framboesiformis 
Interventions:
Device: NdYag Laser(hair removal laser) plus topical corticosteroid;   Drug: Topical corticosteroid alone 
 
 

 
3
Recruiting
Safety and Efficacy of Skin Cleanser Contained Roselle Extract in Acne
Condition:
Acne 
Interventions:
Other: skin cleanser contained Hibiscus sabdariffa extract;   Other: marketed skin cleanser 
 
 

 
4
Not yet recruiting
Photodynamic Therapy in the Treatment of Acne
Condition:
Acne Vulgaris 
Intervention:
Device: LumaCare LC-122M non-coherent light source with LUM-I, fiber optic probe, 610 nm-660 nm output range 
 
 

 
5
Recruiting
A Study to Examine the Safety and Efficacy Of Drospirenone and Ethinyl Estradiol (YAZ) Compared With Placebo In The Treatment Of Moderate Truncal Acne Vulgaris
Condition:
Acne Vulgaris 
Interventions:
Drug: drospirenone and ethinyl estradiol;   Drug: Placebo tablets 
 
 

 
6
Recruiting
Study of Two Different 10.0% Benzoyl Peroxide Creams for Mild to Moderate Acne Vulgaris
Condition:
Acne Vulgaris 
Intervention:
Drug: topical benzoyl peroxide 10.0% cream - Formulations #1 and #2 
 
 

 
7
Recruiting
Trial of Clindamycin / Benzoyl Peroxide Gel in Subjects With Acne
Condition:
Acne Vulgaris 
Interventions:
Drug: clindamycin / benzoyl peroxide gel;   Drug: clindamycin gel;   Drug: BPO gel;   Drug: vehicle gel 
 
 

 
8
Recruiting
Safety and Efficacy Study of Clindamycin/Benzoyl Peroxide/Tazarotene Cream in Subjects With Acne
Condition:
Acne Vulgaris 
Interventions:
Drug: Benzoyl peroxide/clindamycin gel + tazarotene cream;   Drug: Benzoyl peroxide/clindamycin gel + vehicle cream;   Drug: Benzoyl peroxide gel + tazarotene cream;   Drug: Clindamycin gel + tazarotene cream;   Drug: Vehicle gel+ tazarotene cream;   Drug: Vehicle gel + vehicle cream 
 
 

 
9
Recruiting
Evaluation of the Effectiveness, Safety, and Tolerability of Duac Akne Gel and Epiduo Gel in the Treatment of Facial Acne Vulgaris
Condition:
Acne Vulgaris 
Interventions:
Drug: Epiduo Gel;   Drug: Duac Gel 
 
 

 
10
Recruiting
the Comparison Efficacy of Azithromycin With Doxycycline in the Treatment of Acne Vulgaris
Condition:
Acne 
Interventions:
Drug: Doxycycline;   Drug: Azithromycin 
 
 

 
11
Recruiting
Safety and Efficacy of the Use of Botox on Acne
Condition:
Acne Vulgaris 
Interventions:
Drug: Botulinum Neurotoxin Type A;   Drug: Bacteriostatic saline 
 
 

 
12
Recruiting
Study to Compare the Acne Relapse Rate of Oral Minocycline to Oral Minocycline in Combination With Topical Tretinoin, Followed by Topical Tretinoin Alone
Condition:
Acne Vulgaris 
Interventions:
Drug: Minocycline;   Drug: Minocycline + Tretinoin 0.01% 
 
 

 
13
Recruiting
A Study to Evaluate the Efficacy of Silk - Like Bedding Fabric, as Used in a Standard Pillow Case, in the Treatment of Acne Vulgaris
Condition:
Acne Vulgaris 
Interventions:
Device: silk-like fabric standard pillowcase;   Device: pillowcase made of 100% cotton 
 
 

 
14
Recruiting
A Clinical Study to Evaluate the Safety and Effectiveness of an Investigational Product Called W0265 Gel
Conditions:
Acne Vulgaris;   Acne 
Interventions:
Drug: W0265 Gel;   Drug: Clindamycin Gel (clindamycin );   Drug: Tretinoin Gel (tretinoin);   Drug: Vehicle Gel 
 
 

 
15
Not yet recruiting
Topical 5-ALA-PDT With Blu-U Therapy Versus Topical 5-ALA With Pulse Dye Laser In Treating Recalcitrant Acne Vulgaris
Condition:
Acne Vulgaris 
Interventions:
Drug: 5-ALA with Blu-U Light;   Drug: 5-ALA with Candela V-beam Pulse Dye Laser 
 
 

 
16
Recruiting
Adapalene-BPO Gel in the Treatment of Acne Vulgaris as a 6-Month Maintenance
Condition:
Acne 
Interventions:
Drug: Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel;   Drug: Vehicle Gel 
 
 

 
17
Recruiting
Fractional CO2 Treatment of Acne Scars in Asians
Condition:
Acne Scar, Wrinkle 
Intervention:
Device: Fractional CO2 Laser 
 
 

 
18
Recruiting
The Effect of Doxycycline 100mg and Doxycycline 20mg in Treatment of Mild and Moderate Acne
Conditions:
Acne;   Inflammation 
Intervention:
Drug: Doxycycline 
 
 

 
19
Recruiting
Treatment of Acne Scarring With a Novel Procedure Combination
Condition:
Acne Scarring 
Interventions:
Procedure: subdermal manipulation ONLY;   Procedure: subdermal manipulation AND injection of a filler 
 
 

 
20
Recruiting
Injectable POLY-L-Lactic Acid for Treatment of Hill and Valley Acne Scarring
Condition:
Acne Vulgaris 
Intervention:
Device: Sculptra (Poly-L-Lactic Acid Dermal Implant) 
 
 

 
21
Recruiting
 

 
22
Recruiting
Photodynamic Therapy (PDT) With Methyl Aminolevulinate (MAL) Cream in Patients With Skin Type V or IV With Acne Vulgaris
Condition:
Acne Vulgaris 
Intervention:
Drug: Methyl aminolevulinate (MAL) PDT 
 
 

 
23
Recruiting
Pharmacokinetic Study to Compare the Systemic Exposure of Differin® Gel, 0.3% or Differin® Gel, 0.1%
Condition:
Acne Vulgaris 
Interventions:
Drug: Adapalene;   Drug: Adapalene 
 
 

 
24
Recruiting
Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix
Conditions:
Keloid;   Scleroderma, Localized;   Acne Keloidalis;   Scars;   Granuloma Annulare 
Intervention:
Procedure: UVB Irradiation 
 
 

 
25
Recruiting
A Clinical Study Evaluating the Safety and Efficacy of IDP-107 in Patients With Acne Vulgaris
Condition:
Acne Vulgaris 
Interventions:
Drug: Low Strength IDP-107;   Drug: High Strength IDP-107;   Drug: Placebo Comparator 
 
 

 
26
Recruiting
Potential Research Study Participant Registry
Conditions:
Acne;   Actinic Keratosis;   Dysplastic Nevi;   Eczema;   Psoriasis;   Skin Cancer;   Rosacea;   Leg Ulcers;   Foot Ulcers;   Atopic Dermatitis 
Intervention:
 
 
 

 
27
Recruiting
A Study to Examine the Safety and Efficacy of Drospirenone and Ethinyl Estradiol (YAZ) Compared With Placebo In The Treatment Of Hidradenitis Suppurativa
Condition:
Hidradenitis Suppurativa 
Interventions:
Drug: drospirenone and ethinyl estradiol (YAZ);   Drug: Placebo 
 
 

 
28
Recruiting
Regenecare® Wound Gel in Treating Rash in Patients Receiving Cetuximab or Other Epidermal Growth Factor Receptor Inhibitor Therapy for Cancer
Conditions:
Cancer-Related Problem/Condition;   Unspecified Adult Solid Tumor, Protocol Specific 
Interventions:
Drug: collagen/aloe vera/vitamin E/lidocaine topical hydrogel;   Procedure: observation;   Procedure: questionnaire administration 
 
 

 
29
Recruiting
A Study of Continuous Oral Contraceptives and Doxycycline
Condition:
Menstrual Bleeding 
Interventions:
Drug: Lybrel;   Drug: Doxycycline;   Drug: Oracea;   Drug: Placebo 
 
 

 
30
Recruiting
Androgen Therapy for Breast Cancer Patients With Aromatase Inhibitor Induced Side-Effects
Conditions:
Breast Cancer;   Arthralgia;   Osteoporosis 
Intervention:
Drug: Testosterone 
 
 

 
31
Not yet recruiting
Pregnancy in Polycystic Ovary Syndrome II
Conditions:
Pregnancy;   Polycystic Ovary Syndrome 
Interventions:
Drug: Clomiphene citrate;   Drug: Letrozole 
 
 

 
32
Not yet recruiting
VSL#3 Treatment in Children With Crohn's Disease
Condition:
Crohn's Disease 
Interventions:
Dietary Supplement: VSL#3;   Dietary Supplement: Placebo 
 
 

 
33
Recruiting
 

 
34
Recruiting
 

 
35
Recruiting
Natural History Study of Patients With Excess Androgen
Conditions:
Excess Androgen;   Congenital Adrenal Hyperplasia (CAH);   Familial Male-Limited Precocious Puberty (FMPP) 
Intervention: